Arthroscopic Implantation of Adipose-Derived Stromal Vascular Fraction Improves Cartilage Regeneration and Pain Relief in Patients With Knee Osteoarthritis

Kim, Yong Sang; Oh, Sun Mi; Suh, Dong Suk; Tak, Dae Hyun; Kwon, Yoo Beom; Koh, Yong‐Gon

doi:10.1016/j.asmr.2023.03.013

Cited by 4 publications

(1 citation statement)

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“…Rothrauff et al [16] demonstrated that augmenting the repair with a photocrosslinkable hydrogel, which contained SVF cells isolated intraoperatively through rapid enzymatic digestion, enhanced meniscal healing and reduced osteoarthritic changes. A note of optimism emerges from Kim et al [20,21], who reported favorable cartilage regeneration in the SVF group. These findings seem promising for patients suffering from chronic knee OA and looking for alternatives to invasive surgeries (Table 3).…”

Section: Efficacy and Safetymentioning

confidence: 99%

Stromal Vascular Fraction Therapy for Knee Osteoarthritis: A Systematic Review

Goncharov,

Koval,

Nikolaevich Bezuglov

et al. 2023

Medicina

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Background and Objectives: Knee osteoarthritis (OA) is a widespread joint disease, set to increase due to aging and rising obesity. Beyond cartilage degeneration, OA involves the entire joint, including the synovial fluid, bones, and surrounding muscles. Existing treatments, such as NSAIDs and corticosteroid injections, mainly alleviate symptoms but can have complications. Joint replacement surgeries are definitive but carry surgical risks and are not suitable for all. Stromal vascular fraction (SVF) therapy is a regenerative approach using cells from a patient’s adipose tissue. SVF addresses as degenerative and inflammatory aspects, with potential for cartilage formation and tissue regeneration. Unlike traditional treatments, SVF may reverse OA changes. Being autologous, it reduces immunogenic risks. Materials and Methods: A systematic search was undertaken across PubMed, Medline, and Scopus for relevant studies published from 2017 to 2023. Keywords included “SVF”, “Knee Osteoarthritis”, and “Regenerative Medicine”. Results: This systematic search yielded a total of 172 articles. After the removal of duplicates and an initial title and abstract screening, 94 full-text articles were assessed for eligibility. Of these, 22 studies met the inclusion criteria and were subsequently included in this review. Conclusions: This review of SVF therapy for knee OA suggests its potential therapeutic benefits. Most studies confirmed its safety and efficacy, and showed improved clinical outcomes and minimal adverse events. However, differences in study designs and sizes require a careful interpretation of the results. While evidence supports SVF’s positive effects, understanding methodological limitations is key. Incorporating SVF is promising, but the approach should prioritize patient safety and rigorous research.

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Section: Efficacy and Safetymentioning

confidence: 99%