Arthroscopic International Cartilage Repair Society Classification System Has Only Moderate Reliability in a Porcine Cartilage Repair Model

Abstract

Background: The International Cartilage Repair Society (ICRS) score was designed for arthroscopic use to evaluate the quality of cartilage repair. Purpose: To evaluate the reliability of the ICRS scoring system using an animal cartilage repair model. Study Design: Controlled laboratory study. Methods: A chondral defect with an area of 1.5 cm2 was made in the medial femoral condyle of 18 domestic pigs. Five weeks later, 9 pigs were treated using a novel recombinant human type III collagen/polylactide scaffold, and 9 were left to heal spontaneously. After 4 months, the pigs were sacrificed, then 3 arthroscopic surgeons evaluated the medial femoral condyles via video-recorded simulated arthroscopy using the ICRS scoring system. The surgeons repeated the evaluation twice within a 9-month period using their recorded arthroscopy. Results: The porcine cartilage repair model produced cartilage repair tissue of poor to good quality. The mean ICRS total scores for all observations were 6.6 (SD, 2.6) in arthroscopy, 5.9 (SD, 2.7) in the first reevaluation, and 6.2 (SD, 2.8) in the second reevaluation. The interrater reliability with the intraclass correlation coefficient (ICC) for the ICRS total scores (ICC, 0.46-0.60) and for each individual subscore (ICC, 0.26-0.71) showed poor to moderate reliability. The intrarater reliability with the ICC also showed poor to moderate reliability for ICRS total scores (ICC, 0.52-0.59) and for each individual subscore (ICC, 0.29-0.58). A modified Bland-Altman plot for the initial arthroscopy and for the 2 reevaluations showed an evident disagreement among the observers. Conclusion: In an animal cartilage repair model, the ICRS scoring system seems to have poor to moderate reliability. Clinical Relevance: Arthroscopic assessment of cartilage repair using the ICRS scoring method has limited reliability. We need more objective methods with acceptable reliability to evaluate cartilage repair outcomes.

Comparison Between Arthroscopic and Histological International Cartilage Repair Society Scoring Systems in Porcine Cartilage Repair Model

“…However, in our earlier study regarding the reliability of arthroscopic scoring, the intrarater or interrater reliability was not affected by the experience on the evaluator. 24 In addition, the repair tissue was evaluated with arthroscopy in a simulated setup and not in the joint, which may impair the results’ generalization. In the present study, a simulated arthroscopy setting was used because the pig’s stifle joint is small and the experience of a surgeon might affect the diagnostic accuracy of the pig’s stifle joint arthroscopy.…”

A biocompatible pea protein isolate-derived bioink for 3D bioprinting and tissue engineering

“…The distal femurs were isolated, and the quality of regenerated cartilage was evaluated using the International Cartilage Repair Society (ICRS) scoring system. 32 Tissue sections were histologically processed and analyzed using hematoxylin-eosin (HE) staining and saffron red O/fast green staining according to the kit instructions. Additionally, type II collagen was detected via immunohistochemical staining.…”

Preoperative Medial Tightness and Narrow Medial Joint Space Are Predictive Factors for Lower Extremity Alignment Change Toward Varus After Opening-Wedge High Tibial Osteotomy

“…The status of the cartilage on the MFC and MTP was scored using the International Cartilage Regeneration & Joint Preservation Society grading system. 31 The status of the medial meniscal tear was divided into 3 grades as defined in a previous study. 22 A surgical incision was made transversely on the superomedial side of the tibia.…”