Arthroscopic Meniscal Repair With Second-Generation Platelet-Rich Fibrin Clot Augmentation

Narayanaswamy, Ragunanthan; Sha, Ibad

doi:10.1016/j.eats.2022.05.001

Cited by 5 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This would aim to improve cellular integration, vascularization, matrix deposition, and inflammation reduction at the meniscus repair site. 8 Notably, the application of PRP, 3 fibrin clots, 4 , 5 marrow stimulation, 6 and MSCs 7 has shown promising results on the basic science level. 13 , 14 , 15 Following repair with biological augmentation, patients have reported significant improvement in functional outcome scores.…”

Section: Discussionmentioning

confidence: 99%

“…Recent efforts have been made to enhance the healing potential of meniscal repairs. Biologic augmentations, such as platelet-rich plasma (PRP), 3 fibrin clots, 4 , 5 marrow stimulation, 6 and mesenchymal stem cells (MSCs), 7 have shown promising results. 8 These interventions have revealed the ability to promote fibrocyte proliferation, extracellular matrix deposition, and neomeniscal tissue formation, highlighting their potential for improving meniscal repair outcomes.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Repair of a Radial Tear of the Meniscus Augmented With a Biocomposite Scaffold

Wood,

Pyrz,

Lane

et al. 2023

Arthroscopy Techniques

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Repair of a Radial Tear of the Meniscus Augmented With a Biocomposite Scaffold

Wood,

Pyrz,

Lane

et al. 2023

Arthroscopy Techniques

View full text Add to dashboard Cite

“…iPRF application holds better and produces significant functional outcomes in partial meniscectomy. Such iPRF elutes growth factors over 4 weeks, which matches with the healing phase of meniscal tears [86]. Wong et al demonstrated that rabbit's PRF augments meniscal repair by facilitating the proliferation and migration of meniscocytes and enhancing ECM synthesis.…”

Section: Meniscal Injuriesmentioning

confidence: 90%

“…PRF promotes neoangiogenesis as it possesses low thrombin levels for the migration of fibroblasts and endothelial cells, which could help in meniscal healing [85]. Narayanaswamy et al reported the usage of iPRF in meniscal repair and augmentation [86]. iPRF application holds better and produces significant functional outcomes in partial meniscectomy.…”

Section: Meniscal Injuriesmentioning

confidence: 99%

Evolution and Clinical Advances of Platelet-Rich Fibrin in Musculoskeletal Regeneration

Narayanaswamy¹,

Patro

Jeyaraman³

et al. 2023

Bioengineering

Self Cite

View full text Add to dashboard Cite

Over the past few decades, various forms of platelet concentrates have evolved with significant clinical utility. The newer generation products, including leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF), have shown superior biological properties in musculoskeletal regeneration than the first-generation concentrates, such as platelet-rich plasma (PRP) and plasma rich in growth factors. These newer platelet concentrates have a complete matrix of physiological fibrin that acts as a scaffold with a three-dimensional (3D) architecture. Further, it facilitates intercellular signaling and migration, thereby promoting angiogenic, chondrogenic, and osteogenic activities. A-PRF with higher leukocyte inclusion possesses antimicrobial activity than the first generations. Due to the presence of enormous amounts of growth factors and anti-inflammatory cytokines that are released, A-PRF has the potential to replicate the various physiological and immunological factors of wound healing. In addition, there are more neutrophils, monocytes, and macrophages, all of which secrete essential chemotactic molecules. As a result, both L-PRF and A-PRF are used in the management of musculoskeletal conditions, such as chondral injuries, tendinopathies, tissue regeneration, and other sports-related injuries. In addition to this, its applications have been expanded to include the fields of reconstructive cosmetic surgery, wound healing in diabetic patients, and maxillofacial surgeries.

show abstract

“…In 2021, Screpis and colleagues utilized PRF to repair parameniscal cysts, describing their surgical technique 85 . In 2022, Narayanaswamy and Sha described a reproducible and simple way to harvest PRF and create and use a PRF clot, along with detailed instructions on how to integrate the clot with a meniscal repair arthroscopically 86 . Therefore, although studies remain in their infancy, various research groups have demonstrated promising results utilizing i‐PRF for joint injections (Figure 15, Figure S1: QR Code 10 ).…”

Section: Medical Applicationsmentioning

confidence: 99%

Ten years of injectable platelet‐rich fibrin

Miron,

Gruber,

Farshidfar

et al. 2023

Periodontology 2000

View full text Add to dashboard Cite

The use of platelet‐rich fibrin (PRF) has seen widespread advantages over platelet‐rich plasma (PRP) in many fields of medicine. However, until 2014, PRF remained clinically available only in its solid clotted form. Modifications to centrifugation protocols and tube technology have led to the development of a liquid injectable version of PRF (i‐PRF). This narrative review takes a look back at the technological developments made throughout the past decade and further elaborates on their future clinical applications. Topics covered include improvements in isolation techniques and protocols, ways to further concentrate i‐PRF, and the clinical impact and relevance of cooling i‐PRF. Next, various uses of i‐PRF are discussed, including its use in regenerative periodontology, implantology, endodontics, temporomandibular joint injections, and orthodontic tooth movement. Furthermore, various indications in medicine are also covered, including its use in sports injuries and osteoarthritis of various joints, treatment of diabetic ulcers/wound care, and facial esthetics and hair regrowth. Finally, future applications are discussed, mainly its use as a drug delivery vehicle for small biomolecules, such as growth factors, antibiotics, exosomes, and other medications that may benefit from the controlled and gradual release of biomolecules over time.

show abstract

Arthroscopic Meniscal Repair With Second-Generation Platelet-Rich Fibrin Clot Augmentation

Cited by 5 publications

References 30 publications

Repair of a Radial Tear of the Meniscus Augmented With a Biocomposite Scaffold

Repair of a Radial Tear of the Meniscus Augmented With a Biocomposite Scaffold

Evolution and Clinical Advances of Platelet-Rich Fibrin in Musculoskeletal Regeneration

Ten years of injectable platelet‐rich fibrin

Contact Info

Product

Resources

About