Article Commentary: Need for changes in clinical criteria for diagnosing Buerger's disease

Fazeli, Bahare

doi:10.1177/1708538113479537

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…We assessed traditional atherosclerosis risk factors including blood pressure, fasting blood sugar and total cholesterol in this study. Systolic blood pressure below 12 mmHg, diastolic blood pressure below 8 mmHg, fasting blood sugar < 90 mg/dL, and total cholesterol < 180 mg/dL were considered as the upper limits for this assessment . Patients who were in acute phases of their disease were included in this study.…”

Section: Methodsmentioning

confidence: 99%

Sera of patients with thromboangiitis obliterans activated cultured human umbilical vein endothelial cells (HUVECs) and changed their adhesive properties

Fazeli

Rafatpanah²,

Ravari

et al. 2014

Int J Rheum Dis

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Section: Methodsmentioning

confidence: 99%

Sera of patients with thromboangiitis obliterans activated cultured human umbilical vein endothelial cells (HUVECs) and changed their adhesive properties

Fazeli

Rafatpanah²,

Ravari

et al. 2014

Int J Rheum Dis

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“…Young male smokers from low-income and middle-income countries are more likely to get thromboangiitis obliterans (TAO), which is also called Buerger's disease. Blockage of intermediate-sized arteries may cause tissue or limb loss [1,2]. TAO is uncommon globally, with an unknown cause and epidemiology [3].…”

Section: Introductionmentioning

confidence: 99%

“…The clinical criteria proposed by Shionoya were utilized in order to arrive at a diagnosis. These criteria included: (1) a smoking history, (2) an onset that occurred prior to the age of 50 years, (3) infrapopliteal arterial occlusion, (4) either upper limb involvement or phlebitis migrans, and (5) the absence of atherosclerotic risk factors other than smoking [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Transcriptome Profiles in Patients with Thromboangiitis Obliterans

Öztan,

Bozbuğa,

İşsever

et al. 2023

Genes

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Background: Thromboangiitis obliterans (TAO) causes vascular insufficiency due to chronic inflammation and abrupt thrombosis of the medium and small arteries of the extremities. In our study, we aimed to determine biomarkers for the diagnosis of TAO by evaluating 15 male TAO patients with Shinoya diagnostic criteria and 5 healthy controls who did not have TAO-related symptoms in their family histories. Methods: The Clariom D Affymetrix platform was used to conduct microarray analysis on total RNA extracted from whole blood. A total of 477 genes (FC ≤ 5 or >5) common to the fifteen patient and five control samples were selected using comparative microarray analysis; among them, 79 genes were upregulated and 398 genes were downregulated. Results: According to FC ≤ 10 or >10, in the same TAO patient and control group, 13 genes out of 28 were upregulated, whereas 15 genes were downregulated. The 11 key genes identified according to their mean log2FC values were PLP2, RPL27A, CCL4, FMNL1, EGR1, EIF4A1, RPL9, LAMP2, RNF149, EIF4G2, and DGKZ. The genes were ranked according to their relative expression as follows: FMNL1 > RNF149 > RPL27A > EIF4G2 > EIF4A1 > LAMP2 > EGR1 > PLP2 > DGKZ > RPL9 > CCL4. Using protein–protein interaction network analysis, RPL9, RPL27A, and RPL32 were found to be closely related to EIF4G2 and EIF4A1. The Reactome pathway found pathways linked to 28 genes. These pathways included the immune system, cellular responses to stress, cytokine signaling in the immune system, and signaling by ROBO receptors. Conclusions: By figuring out the protein expression levels of the genes that have been found to explain how TAO disease works at the molecular level, it will be possible to figure out how well these chosen transcripts can diagnose and predict the disease.

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Unexpected Inflammation in the Sympathetic Ganglia in Thromboangiitis Obliterans

et al. 2017

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The aim of this study was to inspect more closely the microscopic and molecular sympathetic ganglia histology in thromboangiitis obliterans (TAO). The paraffin block and frozen RNAlater-treated tissue of the lumbar sympathetic ganglia of 19 TAO Caucasian male patients were evaluated. The gene expression of cluster of differentiation 4 (CD4) and cluster of differentiation 8 (CD8) markers in the frozen RNAlater-treated sympathetic ganglia tissues were evaluated by real-time polymerase chain reaction. Unexpectedly, lymphocyte infiltration was observed in all of the histological sections, ranging from scattered to moderate lymphocyte infiltration. In seven patients, five of them underwent below-knee amputation, neutrophil infiltration was observed in addition to lymphocyte infiltration. The gene expression of the CD8 marker in all of the samples with the expression of CD4 markers in only four tissue samples was demonstrated. The expression of CD8 in comparison to CD4 was approximately 4.37-fold changes using Pfaffle method. It appears that inflammation of the sympathetic ganglia plays a role in the pathophysiology of TAO and its outcome. Sympathetic ganglia inflammation may be responsible for general vasoconstriction, vascular inflammation, and the increased risk of thrombotic events, by activating the platelets. The dominant infiltration of T cytotoxic lymphocytes and neutrophils in sympathetic ganglia may probably support the idea of possible intracellular infectious pathogen trigger for TAO and consequently infiltration of pathogen-specific T cells into the sympathetic ganglia in TAO.

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Article Commentary: Need for changes in clinical criteria for diagnosing Buerger's disease

Cited by 4 publications

References 11 publications

Sera of patients with thromboangiitis obliterans activated cultured human umbilical vein endothelial cells (HUVECs) and changed their adhesive properties

Sera of patients with thromboangiitis obliterans activated cultured human umbilical vein endothelial cells (HUVECs) and changed their adhesive properties

Comparative Analysis of Transcriptome Profiles in Patients with Thromboangiitis Obliterans

Unexpected Inflammation in the Sympathetic Ganglia in Thromboangiitis Obliterans

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