ARTICLE: Compromised Skin Barrier and Sensitive Skin in Diverse Populations

Wu, Yang‐Chang; Wangari-Olivero, Janet; Zhen, Yaxian

doi:10.36849/jdd.589c

Cited by 7 publications

(2 citation statements)

References 26 publications

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“…Asian skin may be more sensitive to exogenous chemicals due to an intrinsically thinner stratum corneum and higher density of eccrine glands [ 22 ]. Despite having the lowest ceremide levels, darker skin types may have a stronger barrier against chemical or mechanical insults [ 22 ] due to the presence of a more compact stratum corneum [ 23 ]. Muizzuddina et al [ 24 ] investigated the differences in skin barrier function and structural elements of the stratum corneum of African Americans, Caucasians, and East Asians who lived in the same geographical region to reduce the impact of environmental exposure differences and found that East Asian skin is more sensitive than Caucasian skin, which is, in turn, more reactive than the skin of African Americans, because East Asian skin, and to some extent Caucasian skin, had low maturation and relatively weaker skin barrier.…”

Section: Resultsmentioning

confidence: 99%

Are There Ethnic Differences in Hand Eczema? A Review

Chai

Tey

Lim

2023

JCM

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Hand eczema is a common disease with economic and social ramifications. This study undertakes a review of certain existing literature to provide insight into contributory factors which may result in the varying prevalence and severity of hand eczema among different ethnic groups, particularly to identify modifiable risk factors, as well as to ascertain knowledge gaps for future research direction. The existing literature suggests that factors including (a) genes, (b) differing skin physiology, (c) cultural practices, (d) dietary habits and associated food preparation, (e) climate, (f) predominant occupations, (g) socioeconomic factors, and (h) dissimilar laws and regulations may account for the disparity in the risk of hand eczema among different ethnicities. Given that endogenous factors cannot be avoided, but certain exogenous aspects can be modified, especially as the environment plays an important role in hand eczema flares, it is helpful from a practical perspective to focus on addressing the modifiable risk factors. These factors pertain to unique cultural practices, customs, and food preparation methods. Healthcare professionals should be well-acquainted with such factors to tailor the treatment approach for patients of different ethnicities accordingly because, with globalization, physicians face increasingly diverse patient populations such that cultural customs no longer remain limited to particular geographic regions.

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Section: Resultsmentioning

confidence: 99%

Are There Ethnic Differences in Hand Eczema? A Review

Chai

Tey

Lim

2023

JCM

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“…Defective skin barrier function, leading to increased transepidermal water loss (TEWL) and decreased SC hydration (dry skin), is a characteristic feature of AD. An impaired skin barrier plays a significant role in various skin conditions, such as dry skin (as a condition itself), sensitive skin, seborrheic dermatitis, contact dermatitis, or AD [ 29 , 30 ].…”

Section: Overview Of Ad and Treatment Optionsmentioning

confidence: 99%

Use of Dexpanthenol for Atopic Dermatitis—Benefits and Recommendations Based on Current Evidence

Cho

Kim

Woo

et al. 2022

JCM

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Background: Atopic dermatitis (AD) is an inflammatory skin disease of multiple phenotypes and endotypes, and is highly prevalent in children. Many people of all ages, including active adolescents, pregnant women, and the elderly, suffer from AD, experiencing chronicity, flares, and unexpected relapse. Dexpanthenol has multiple pharmacological effects and has been employed to treat various skin disorders such as AD. We aimed to summarize the up-to-date evidence relating to dexpanthenol and to provide a consensus on how to use dexpanthenol effectively for the treatment of AD. Methods: The evidence to date on the application and efficacy of dexpanthenol in AD was reviewed. The literature search focused on dexpanthenol use and the improvement of skin barrier function, the prevention of acute flares, and its topical corticosteroid (TCS) sparing effects. Evidence and recommendations for special groups such as pregnant women, and the effects of dexpanthenol and emollient plus in maintenance therapy, were also summarized. Results: Dexpanthenol is effective and well-tolerated for the treatment of AD. Dexpanthenol improves skin barrier function, reduces acute and frequent flares, has a significant TCS sparing effect, and enhances wound healing for skin lesions. Conclusion: This review article provides helpful advice for clinicians and patients on the proper maintenance treatment of AD. Dexpanthenol, as an active ingredient in ointments or emollients, is suitable for the treatment and maintenance of AD. This paper will guide dermatologists and clinicians to consider dexpanthenol as a treatment option for mild to moderate AD.

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