Articular cartilage: New directions and barriers of scaffolds development – review

Urbanek, Olga; Kołbuk, Dorota; Wróbel, Mikołaj

doi:10.1080/00914037.2018.1452224

Cited by 19 publications

(14 citation statements)

References 137 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Devices are constantly being developed in an effort to address this currently unmet need with varying degrees of success [ 6 , 7 ]. The challenges and current device technologies to address regeneration have been recently reviewed for both articular cartilage [ 8 ] and the osteochondral interface [ 9 ]. Effective design requires intimate knowledge of the local tissue environment and matching of these mechanical properties with the intended device [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model

et al. 2020

View full text Add to dashboard Cite

Osteochondral injuries are increasingly prevalent, yet success in articular cartilage regeneration remains elusive, necessitating the development of new surgical interventions and novel medical devices. As part of device development, animal models are an important milestone in illustrating functionality of novel implants. Inspection of the tissue-biomaterial system is vital to understand and predict load-sharing capacity, fixation mechanics and micromotion, none of which are directly captured by traditional post-mortem techniques. This study aims to characterize the localised mechanics of an ex vivo ovine osteochondral tissue–biomaterial system extracted following six weeks in vivo testing, utilising laboratory micro-computed tomography, in situ loading and digital volume correlation. Herein, the full-field displacement and strain distributions were visualised across the interface of the system components, including newly formed tissue. The results from this exploratory study suggest that implant micromotion in respect to the surrounding tissue could be visualised in 3D across multiple loading steps. The methodology provides a non-destructive means to assess device performance holistically, informing device design to improve osteochondral regeneration strategies.

show abstract

Section: Introductionmentioning

confidence: 99%

Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Thus, this kind of membrane does not have suitable properties to create hyaline cartilage. As a result of regeneration, non-valuable fibrous cartilage is obtained, which is susceptible to future damage [ 40 , 50 , 51 , 57 , 76 , 111 , 156 , 173 ].…”

Section: Scaffolds For Cartilage Treatmentmentioning

confidence: 99%

Review of Synthetic and Hybrid Scaffolds in Cartilage Tissue Engineering

2020

View full text Add to dashboard Cite

Cartilage tissue is under extensive investigation in tissue engineering and regenerative medicine studies because of its limited regenerative potential. Currently, many scaffolds are undergoing scientific and clinical research. A key for appropriate scaffolding is the assurance of a temporary cellular environment that allows the cells to function as in native tissue. These scaffolds should meet the relevant requirements, including appropriate architecture and physicochemical and biological properties. This is necessary for proper cell growth, which is associated with the adequate regeneration of cartilage. This paper presents a review of the development of scaffolds from synthetic polymers and hybrid materials employed for the engineering of cartilage tissue and regenerative medicine. Initially, general information on articular cartilage and an overview of the clinical strategies for the treatment of cartilage defects are presented. Then, the requirements for scaffolds in regenerative medicine, materials intended for membranes, and methods for obtaining them are briefly described. We also describe the hybrid materials that combine the advantages of both synthetic and natural polymers, which provide better properties for the scaffold. The last part of the article is focused on scaffolds in cartilage tissue engineering that have been confirmed by undergoing preclinical and clinical tests.

show abstract

“…Phase inversion (dry and wet phase inversion), freeze‐extraction, thermally induced phase separation (TIPS), freeze‐drying (Pant et al, 2019; Pant, Sundaram, Goudie, Nguyen, & Handa, 2019), salt‐leaching, gas‐foaming, electrospinning (Dulnik, Kołbuk, Denis, & Sajkiewicz, 2018; Kołbuk, Urbanek, Denis, & Choińska, 2019), and rapid prototyping techniques: stereolithography (SLA), selective laser sintering (SLS), fused deposition modeling (FDM) (Budnicka, Gadomska‐Gajadhur, & Ruśkowski, 2019; Kosik‐Koziol et al, 2019; Liu & Ma, 2004; Liu Tsang & Bhatia, 2004; Rezwan, Chen, Blaker, & Boccaccini, 2006) may be distinguished. All the above have their advantages and disadvantages, described, among others (Jeznach, Kolbuk, & Sajkiewicz, 2018; Urbanek, Kołbuk, & Wróbel, 2019). The freeze‐extraction method does not require specialist apparatus and provides the ability to change many factors affecting the structure.…”

Section: Introductionmentioning

confidence: 98%

Poly‐L‐lactide scaffolds with super pores obtained by freeze‐extraction method

et al. 2020

Self Cite

View full text Add to dashboard Cite

A nonplanar polylactide scaffold to be used in tissue engineering was obtained by freeze-extraction method. Properties of the scaffold were modified by adding Eudragit ® E100. The impact of the modification on morphology, porosity and pore size, mass absorbability, mechanical properties was determined. Scanning electron microscopy (SEM), hydrostatic weighing test, static compression test was used to this end. The chemical composition of the scaffold was defined based on infrared spectroscopy (FTIR) and energy-dispersive X-ray spectroscopy (EDX). Biocompatibility was confirmed by quantitative tests and microscopic observation. The obtained results show that the obtained scaffolds may be applied as a carrier of hydrophilic cellular growth factors for more efficient tissue regeneration.

show abstract

Articular cartilage: New directions and barriers of scaffolds development – review

Cited by 19 publications

References 137 publications

Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model

Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model

Review of Synthetic and Hybrid Scaffolds in Cartilage Tissue Engineering

Poly‐L‐lactide scaffolds with super pores obtained by freeze‐extraction method

Contact Info

Product

Resources

About