Articular mastocytosis in the tarsocrural joint of a horse

Taylor, Sarah L.; Martinelli, M; Trostle, Steven S.; Kemper, Thomas L.

doi:10.1111/j.2042-3292.2005.tb00373.x

Cited by 15 publications

(25 citation statements)

References 9 publications

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“…2,[9][10][11][12] Other treatments include intralesional corticosteroids, cryosurgery, and radiotherapy. 3,7,8,13 In this case, intralesional injection of triamcinolone and oral dexamethasone reduced the size of the mast cell tumor on the head, but the leg swelling, pruritus and self-trauma ultimately could not be controlled. Mast cell degranulation from trauma or natural tendon movement may have caused the pruritus and locally extensive edema.…”

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confidence: 76%

“…2,3 One of the horses responded to joint lavage and corticosteroid treatment. 3 However, similar to the present case the other horse had severe pruritus and lameness; euthanasia was the outcome. 2 The eosinophilic inflammation in joint aspirates in the 2 cases with articular mastocytosis are similar to the present case.…”

mentioning

confidence: 99%

“…[2][3][4] In both cases of articular mastocytosis, eosinophilic inflammation of joint aspirates was prominent while mast cells were either rare or not evident; biopsy of synovial membranes were required for diagnosis. 2,3 One of the horses responded to joint lavage and corticosteroid treatment. 3 However, similar to the present case the other horse had severe pruritus and lameness; euthanasia was the outcome.…”

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confidence: 99%

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Cutaneous and Tendon Sheath Mastocytomas with Eosinophilic Joint and Tendon Sheath Effusions in a Horse

Uehlinger

Burton

Riley

et al. 2010

Journal of Veterinary Internal Medicine

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A 4.5-year-old Quarter Horse gelding was referred for evaluation of a swollen right hind leg of 3 weeks duration, which had occurred after exercise. Lameness was not observed and cold hydrotherapy had resulted in little improvement. Two weeks before presentation, the gelding developed a swelling over the left zygomatic arch for which a tentative diagnosis of abscessation was made. However, the lesion was unresponsive to antibiotics, became pruritic, ulcerated, and exuded serosanguinous fluid. Two days before presentation, dexamethasone powder a was prescribed to treat the leg swelling. On the day of presentation, the gelding also developed a swelling overlying the xiphoid process and a swelling on the right lateral abdomen.At presentation, the gelding weighed 546 kg and had normal vital signs. The right hind fetlock was swollen circumferentially from the distal third of the metatarsus to the pastern. The swelling was warm, firm, and nonpitting. The gelding was grade 1/5 lame in the affected limb.1 The mass (5 cm diameter, 2 cm depth) over the zygomatic arch was firm, ulcerated, and immoveable. The xiphoid process swelling (1 cm diameter, 1 cm depth) was soft, nonfluctuant, and nonmobile. The soft tissue swelling (15 cm diameter, 1 cm depth) on the right lateral abdomen resembled cutaneous edema.Biochemical and hematologic values were within reference intervals except for mild eosinophilia. Radiographs of the right hind fetlock revealed a discrete osteophyte on the dorso-medial aspect of the 1st phalanx. Skull radiographs showed a discrete soft tissue swelling surrounding the left zygomatic arch.Ultrasonography of the right metatarsal area revealed thickening of the subcutaneous tissues (1.1 cm depth) and distention (3.5 cm diameter, 1.5 cm depth) of the digital flexor tendon sheath with anechoic fluid at the level of the fetlock and pastern.Histopathologic evaluation of a 5-mm-diameter punch biopsy from the mass on the head revealed a poorly defined tumor involving the subcutis and deep dermis. It was composed of multiple, densely cellular islands and nests of pale, neoplastic round cells embedded in large amounts of dense fibrous stroma. Mild-to-moderate infiltrates of eosinophils surrounded these neoplastic aggregates. Tumor cells had pale eosinophilic cytoplasm, uniform oval nuclei with finely stippled chromatin, and inapparent to single small nucleoli. Toluidine-blue staining revealed many fine metachromatic cytoplasmic granules. No mitotic figures were observed. This mass was diagnosed as a cutaneous mast cell tumor. Histopathologic evaluation of two 5-mm-diameter punch biopsies of the mass overlying the xiphoid process revealed marked subcutaneous fibrosis containing mild infiltrates of eosinophils with fewer lymphocytes and plasma cells. There was no evidence of neoplasia. The subcutis contained rare discrete aggregates of cell debris, amorphous hypereosinophilic material, and occasional hyalinized fragmented collagen fibers surrounded by a rim of epithelioid macrophages admixed with eosinophils consisten...

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confidence: 76%

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confidence: 99%

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confidence: 99%

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Cutaneous and Tendon Sheath Mastocytomas with Eosinophilic Joint and Tendon Sheath Effusions in a Horse

Uehlinger

Burton

Riley

et al. 2010

Journal of Veterinary Internal Medicine

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“…Mast cell tumours have also been reported involving the eye, affecting the conjunctiva, sclera, membrana nictitans and globe (Martin and Leipold 1972;Doran and Collins 1986;Hum and Bowers 1989;McEntee 1991;Lavach 1992;Nyrop 1992;Ward et al 1993;Malikides et al 1996), the nasal cavity and nasopharynx (McEntee 1991;Richardson et al 1994;Malikides et al 1996), trachea (Wenger and Caron 1988), and tongue (Seeliger et al 2007). A recent report (Taylor et al 2005) also described a mast cell tumour that originated within the synovial membrane of the tarsocrural joint, with no external cutaneous masses.…”

Section: Clinical Features Of Previously Reported Casesmentioning

confidence: 99%

Mast cell tumours (mastocytosis) in the horse: A review of the literature and report of 11 cases

Mair

Krudewig

2008

Equine Veterinary Education

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Mast cell tumours are uncommon tumours in horses, compared to some other species of domesticated animals. They are most frequently located in the skin, but they can also arise at other sites, including the upper respiratory tract and eye. Cytology or histopathology is required for diagnosis. Treatment options include surgical excision, laser ablation, cryotherapy, intralesional injection of corticosteroids or water, and radiotherapy. Malignant and systemic forms are very rare.

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“…A congenital multifocal cutaneous form has been reported in foals at or shortly after birth, which is characterised by spontaneous regression (Prasse et al 1975). The second more common form is typically associated with the production of benign, solitary nodules of the head, neck, trunk or limbs of mature horses of all ages (Whitler et al 1994;Malikides et al 1996;Reppas and Canfield 1996;Johnson 1998;Taylor et al 2005;Cole et al 2007). The cutaneous form has been most commonly reported in male Arabian horses where most affected horses had favourable outcomes following complete surgical excision, although metastases to local lymph nodes has been reported in isolated cases (Reppas and Canfield 1996;Carr 2006;Cole et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Unilateral testicular mastocytoma in a Peruvian Paso stallion

Brown

O'Brien

Hodder

et al. 2008

Equine Veterinary Education

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A 12-year-old Peruvian Paso stallion was examined for scrotal swelling and unilateral testicular enlargement of 4-6 weeks duration. Physical examination and ultrasonography of the scrotum revealed an enlarged, nonpainful right testis with a well encapsulated mass at the cranial-medial aspect containing echodense flocculent material. Unilateral castration was performed and the testis, spermatic cord and vaginal tunic were submitted for histological examination, which revealed a mastocytoma with accompanying evidence of malignancy. Short-term follow-up examination did not reveal any evidence of abdominal metastasis and the stallion has since successfully achieved pregnancy in a small number of mares. Although considered rare, mast cell neoplasia should be considered as a differential diagnosis when unilateral testicular enlargement is encountered.

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Articular mastocytosis in the tarsocrural joint of a horse

Cited by 15 publications

References 9 publications

Cutaneous and Tendon Sheath Mastocytomas with Eosinophilic Joint and Tendon Sheath Effusions in a Horse

Cutaneous and Tendon Sheath Mastocytomas with Eosinophilic Joint and Tendon Sheath Effusions in a Horse

Mast cell tumours (mastocytosis) in the horse: A review of the literature and report of 11 cases

Unilateral testicular mastocytoma in a Peruvian Paso stallion

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