Robots can provide assistance to a human by moving objects to locations around the person's body. With a well chosen initial configuration, a robot can better reach locations important to an assistive task despite model error, pose uncertainty and other sources of variation. However, finding effective configurations can be challenging due to complex geometry, a large number of degrees of freedom, task complexity and other factors. We present task-centric optimization of robot configurations (TOC), which is an algorithm that finds configurations from which the robot can better reach task-relevant locations and handle task variation. Notably, TOC can return more than one configuration that when used sequentially enable a simulated assistive robot to reach more task-relevant locations. TOC performs substantial offline computation to generate a function that can be applied rapidly online to select robot configurations based on current observations. TOC explicitly models the task, environment, and user, and implicitly handles error using representations of robot dexterity. We evaluated TOC in simulation with a PR2 assisting a user with 9 assistive tasks in both a wheelchair and a robotic bed. TOC had an overall average success rate of 90.6% compared to 50.4%, 43.5%, and 58.9% for threeWe thank Henry and Jane Evans for providing input on assistive tasks and actuated beds. We also thank Daehyung Park and Zackory Erickson for their valuable feedback. Fig. 1: TOC can select a configuration for the PR2 and the robotic bed so the PR2 can better reach task-relevant locations. This figure shows the configuration for the task of a PR2 cleaning the legs of a person in a robotic bed. baseline methods from literature. We additionally demonstrate how TOC can find configurations for more than one robot and can be used to assist in designing or optimizing environments.