Articulatory undershoot of vowels in isolated REM sleep behavior disorder and early Parkinson’s disease

Skrabal, Dominik; Rusz, Ján; Novotný, Michal; Šonka, Karel; Růžička, Evžen; Dušek, Petr; Tykalová, Tereza

doi:10.1038/s41531-022-00407-7

Cited by 9 publications

(2 citation statements)

References 51 publications

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“…Previous studies investigated the speech production in iRBD patients on the acoustic level. A reduced ability to modulate pitch was observed in speakers with iRBD [4][5][6] : Besides monopitch, articulatory deficits were reported most dominant 7 leading to a reduction of the acoustic vowel space was determined 8 as well as a trend towards lower articulation rates 5 . While acoustic speech parameters deviated between speakers with iRBD and a control group, no perceptual differences were identified by listeners 5 .…”

Section: Introductionmentioning

confidence: 96%

Compensatory mechanisms enables intelligibility in prodromal Parkinson’s disease

Thies

Mücke

Geerts

et al. 2022

Preprint

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Background: Speech impairment is already present on the acoustic level in speakers with isolated rapid eye movement sleep behavior disorder (iRBD). The aim of this study was to determine whether speech changes are already present on the articulatory level and if how these differ from healthy control speakers and speakers with Parkinson's disease (PD). Methods: Kinematic data were collected from 68 age and sex-matched subjects: healthy control speakers (n=23), patients with iRBD (n=22), and patients with PD (n=23). All participants were recorded with electromagnetic articulography (AG 501) to capture articulatory movements of the lower lip, the tongue tip and the tongue body. Movement amplitudes, durations and average speeds were calculated per articulator. In addition, naive listeners rated the intelligibility of the speech sampled produced by the participants. Results: The results of the production experiment indicate changes between the control and the iRBD group as well as between the iRBD and the PD group. Movement durations increase from the control group to the iRBD group and further to the PD group. In contrary, movement amplitudes increase in prodromal PD and decreased from PD onwards. This relationship was reflected by preserved articulatory speed in iRBD patients, but articulatory slowdown in PD. Intelligibility is lower in speakers with PD, but does not differ between the control and the iRBD group. Conclusion: Speakers with iRBD adjust underlying articulatory movement patterns to maintain their intelligibility level.

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Section: Introductionmentioning

confidence: 96%

Compensatory mechanisms enables intelligibility in prodromal Parkinson’s disease

Thies

Mücke

Geerts

et al. 2022

Preprint

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“…The tongue is a primary articulator of vowels, and bulbar muscle weakness in patients with ALS is usually more prominent in the tongue than other bulbar muscles such as the lips and jaw [11,12]. Impairment of vowel articulation has been identified as a potential surrogate marker for neurodegenerative disorders, such as Parkinson's disease (PD), and can even be observed in individuals with rapid eye movement sleep behavior disorder, which is considered a prodromal stage of PD [13,14]. This impairment may worsen as the disease progresses [15].…”

Section: Introductionmentioning

confidence: 99%

Subclinical articulatory changes of vowel parameters in Korean amyotrophic lateral sclerosis patients with perceptually normal voices

Kim,

Jang,

Choi

et al. 2023

PLoS ONE

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The available quantitative methods for evaluating bulbar dysfunction in patients with amyotrophic lateral sclerosis (ALS) are limited. We aimed to characterize vowel properties in Korean ALS patients, investigate associations between vowel parameters and clinical features of ALS, and analyze subclinical articulatory changes of vowel parameters in those with perceptually normal voices. Forty-three patients with ALS (27 with dysarthria and 16 without dysarthria) and 20 healthy controls were prospectively collected in the study. Dysarthria was assessed using the ALS Functional Rating Scale-Revised (ALSFRS-R) speech subscores, with any loss of 4 points indicating the presence of dysarthria. The structured speech samples were recorded and analyzed using Praat software. For three corner vowels (/a/, /i/, and /u/), data on the vowel duration, fundamental frequency, frequencies of the first two formants (F1 and F2), harmonics-to-noise ratio, vowel space area (VSA), and vowel articulation index (VAI) were extracted from the speech samples. Corner vowel durations were significantly longer in ALS patients with dysarthria than in healthy controls. The F1 frequency of /a/, F2 frequencies of /i/ and /u/, the VSA, and the VAI showed significant differences between ALS patients with dysarthria and healthy controls. The area under the curve (AUC) was 0.912. The F1 frequency of /a/ and the VSA were the major determinants for differentiating ALS patients who had not yet developed apparent dysarthria from healthy controls (AUC 0.887). In linear regression analyses, as the ALSFRS-R speech subscore decreased, both the VSA and VAI were reduced. In contrast, vowel durations were found to be rather prolonged. The analyses of vowel parameters provided a useful metric correlated with disease severity for detecting subclinical bulbar dysfunction in ALS patients.

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Smartphone Voice Calls Provide Early Biomarkers of Parkinsonism in Rapid Eye Movement Sleep Behavior Disorder

Illner,

Novotný,

Kouba

et al. 2024

Movement Disorders

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BackgroundSpeech dysfunction represents one of the initial motor manifestations to develop in Parkinson's disease (PD) and is measurable through smartphone.ObjectiveThe aim was to develop a fully automated and noise‐resistant smartphone‐based system that can unobtrusively screen for prodromal parkinsonian speech disorder in subjects with isolated rapid eye movement sleep behavior disorder (iRBD) in a real‐world scenario.MethodsThis cross‐sectional study assessed regular, everyday voice call data from individuals with iRBD compared to early PD patients and healthy controls via a developed smartphone application. The participants also performed an active, regular reading of a short passage on their smartphone. Smartphone data were continuously collected for up to 3 months after the standard in‐person assessments at the clinic.ResultsA total of 3525 calls that led to 5990 minutes of preprocessed speech were extracted from 72 participants, comprising 21 iRBD patients, 26 PD patients, and 25 controls. With a high area under the curve of 0.85 between iRBD patients and controls, the combination of passive and active smartphone data provided a comparable or even more sensitive evaluation than laboratory examination using a high‐quality microphone. The most sensitive features to induce prodromal neurodegeneration in iRBD included imprecise vowel articulation during phone calls (P = 0.03) and monopitch in reading (P = 0.05). Eighteen minutes of speech corresponding to approximately nine calls was sufficient to obtain the best sensitivity for the screening.ConclusionWe consider the developed tool widely applicable to deep longitudinal digital phenotyping data with future applications in neuroprotective trials, deep brain stimulation optimization, neuropsychiatry, speech therapy, population screening, and beyond. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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Articulatory undershoot of vowels in isolated REM sleep behavior disorder and early Parkinson’s disease

Cited by 9 publications

References 51 publications

Compensatory mechanisms enables intelligibility in prodromal Parkinson’s disease

Compensatory mechanisms enables intelligibility in prodromal Parkinson’s disease

Subclinical articulatory changes of vowel parameters in Korean amyotrophic lateral sclerosis patients with perceptually normal voices

Smartphone Voice Calls Provide Early Biomarkers of Parkinsonism in Rapid Eye Movement Sleep Behavior Disorder

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