Artifacts in postmortem CT-imaging of the brain: A cooling effect?

Thicot, Frederique; Dunet, Vincent; Magnin, Virginie; Bruguier, Christine; Lobrinus, Johannes-Alexander; Grabherr, Silke; Genet, Pia

doi:10.1016/j.fsir.2023.100342

Forensic Science International: Reports

2023

DOI: 10.1016/j.fsir.2023.100342

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Artifacts in postmortem CT-imaging of the brain: A cooling effect?

Frederique Thicot,

Vincent Dunet,

Virginie Magnin

et al.

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2024

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Cited by 2 publications

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Ultrahigh-resolution 7-Tesla anatomic magnetic resonance imaging and diffusion tensor imaging of ex vivo formalin-fixed human brainstem-cerebellum complex

Hanalioglu,

Bahadir,

Ozak

et al. 2024

Front. Hum. Neurosci.

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IntroductionBrain cross-sectional images, tractography, and segmentation are valuable resources for neuroanatomical education and research but are also crucial for neurosurgical planning that may improve outcomes in cerebellar and brainstem interventions. Although ultrahigh-resolution 7-Tesla (7T) magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) reveal such structural brain details in living or fresh unpreserved brain tissue, imaging standard formalin-preserved cadaveric brain specimens often used for neurosurgical anatomic studies has proven difficult. This study sought to develop a practical protocol to provide anatomic information and tractography results of an ex vivo human brainstem-cerebellum specimen.Materials and methodsA protocol was developed for specimen preparation and 7T MRI with image postprocessing on a combined brainstem-cerebellum specimen obtained from an 85-year-old male cadaver with a postmortem interval of 1 week that was stored in formalin for 6 months. Anatomic image series were acquired for detailed views and diffusion tractography to map neural pathways and segment major anatomic structures within the brainstem and cerebellum.ResultsComplex white matter tracts were visualized with high-precision segmentation of crucial brainstem structures, delineating the brainstem-cerebellum and mesencephalic-dentate connectivity, including the Guillain-Mollaret triangle. Tractography and fractional anisotropy mapping revealed the complexities of white matter fiber pathways, including the superior, middle, and inferior cerebellar peduncles and visible decussating fibers. 3-dimensional (3D) reconstruction and quantitative and qualitative analyses verified the anatomical precision of the imaging relative to a standard brain space.DiscussionThis novel imaging protocol successfully captured the intricate 3D architecture of the brainstem-cerebellum network. The protocol, unique in several respects (including tissue preservation and rehydration times, choice of solutions, preferred sequences, voxel sizes, and diffusion directions) aimed to balance high resolution and practical scan times. This approach provided detailed neuroanatomical imaging while avoiding impractically long scan times. The extended postmortem and fixation intervals did not compromise the diffusion imaging quality. Moreover, the combination of time efficiency and ultrahigh-resolution imaging results makes this protocol a strong candidate for optimal use in detailed neuroanatomical studies, particularly in presurgical trajectory planning.

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Ultrahigh-resolution 7-Tesla anatomic magnetic resonance imaging and diffusion tensor imaging of ex vivo formalin-fixed human brainstem-cerebellum complex

Hanalioglu,

Bahadir,

Ozak

et al. 2024

Front. Hum. Neurosci.

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Virtopsy: Development and Application in Forensic Practice

Zou,

Liu,

Liu

et al. 2024

Journal of Forensic Science and Medicine

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Although represents traditional and classical examination in forensic medicine, nowadays, autopsy, sometimes, is still rejected or not tolerated for its damage to the corpse. Virtopsy offers a noninvasive investigation approach and can also reflect fracture, soft-tissue injury, wound track, and organ trauma objectively and accurately. In addition, virtual autopsies can be used as a complementary tool for areas that are difficult or complex to dissect; in certain cases, where the destruction of a body is prohibited, virtual autopsies provide an alternative to traditional autopsies as an examination method. The virtual autopsy can scan and record a body from head to toe in a short, quick operation, which greatly improves the efficiency of forensic identification. On the other hand, the virtual autopsy is permanently stored through DICOM data and can be subject to a variety of postprocessing operations. Virtual autopsy provides two-dimensional and three-dimensional postprocessing techniques, combining surface and in vivo information with geometrically realistic records, and even combining with finite elements for computer-simulated dynamic simulation studies. Thus, virtopsy can provide visual and powerful evidence for forensic pathological practice. This article mainly synthesizes the latest literature and reviews the application of virtopsy in forensic trauma identification, mechanical asphyxia, drowning, hypothermia and hyperthermia, disease diagnosis, as well as a new research direction of finite element method applied in trauma investigation.

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Artifacts in postmortem CT-imaging of the brain: A cooling effect?

Cited by 2 publications

References 24 publications

Ultrahigh-resolution 7-Tesla anatomic magnetic resonance imaging and diffusion tensor imaging of ex vivo formalin-fixed human brainstem-cerebellum complex

Ultrahigh-resolution 7-Tesla anatomic magnetic resonance imaging and diffusion tensor imaging of ex vivo formalin-fixed human brainstem-cerebellum complex

Virtopsy: Development and Application in Forensic Practice

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