Artificial Cells and Bioencapsulation in Bioartificial Organs<sup>a</sup>

Chang, Thomas Ming Swi

doi:10.1111/j.1749-6632.1997.tb52200.x

Cited by 17 publications

(5 citation statements)

References 25 publications

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“…In general, such therapies have the potential for the treatment of diseases requiring enzyme or endocrine replacement as well as in nutrient delivery via the encapsulation of enzymes, bacteria or cells. Examples of these medical applications are the encapsulation of islets of Langerhans for the treatment of diabetes mellitus, the use of encapsulated bioartificial organs targeted at treating neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, and Huntington's chorea, and in the control of chronic pain and the administration of human growth factors 3…”

Section: Introductionmentioning

confidence: 99%

“…Examples of these medical applications are the encapsulation of islets of Langerhans for the treatment of diabetes mellitus, the use of encapsulated bioartificial organs targeted at treating neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, and Huntington's chorea, and in the control of chronic pain and the administration of human growth factors. 3 During the past two decades, due to the possibility of unique formation under physiological conditions and potential applications as microcapsules for medical implants, a variety of approaches based on polyelectrolyte complexes (PECs) have been studied. Several systems based on various polymer chemistries, processes of membrane formation, and encapsulation technologies have been evaluated.…”

Section: Introductionmentioning

confidence: 99%

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Optimal Conditions of Transplantable Binary Polyelectrolyte Microcapsules

Bartkowiak

2001

Annals of the New York Academy of Sciences

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Binary polyanion/oligocation microcapsules, prepared in a one‐step process, are proposed as an alternative to the common alginate/poly‐l‐lysine system used in bioencapsulation technology. The model system is based on natural polysaccharides and involves the anionic sodium alginate, or iota‐carrageenan, complexed with cationic oligochitosan. This system has been characterized with respect to capsule formation, mechanical strength, and permeability. This paper provides a general description of the influence of the most pronounced parameters that can be used as a tool to modulate the properties of binary microcapsules. These parameters have been separated into two categories. The first, which includes molar mass of polyanion, pH, ionic strength, and concentration of both polyelectrolytes, can be used to simultaneously control capsule mechanical and structural properties. The second set, molar mass of polyanion and reaction time, influences only mechanical resistance without altering membrane permeability. Additional issues related to mechanical stability and the possible change of capsule properties following transplantation are discussed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optimal Conditions of Transplantable Binary Polyelectrolyte Microcapsules

Bartkowiak

2001

Annals of the New York Academy of Sciences

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“…As long as forty years ago Chang proposed microencapsulation as a possible tool to create artificial organs. 1 Owing to the lack of mild procedures for preparing microcapsules, all attempts to encapsulate viable cells or sensitive biological material without serious damage failed in the beginning. It took almost 30 more years until a breakthrough was achieved by Lim and Sun, 2 who invented the now well-known Alginate/L-Polylysine (ALG/PLL) procedure and described the first successful immobilization of islets of Langerhans.…”

Section: Introductionmentioning

confidence: 99%

Development of Cellulose Sulfate‐based Polyelectrolyte Complex Microcapsules for Medical Applications

Dautzenberg

Schuldt

Grasnick

et al. 1999

Annals of the New York Academy of Sciences

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Microencapsulation, as a tool for immunoisolation for allogenic or xenogenic implants, is a rapidly growing field. However most of the approaches are based on alginate/polylysine capsules, despite this system's obvious disadvantages such as its pyrogenicity. Here we report a different encapsulation system based on sodium cellulose sulfate and polydiallyldimethyl ammonium chloride for the encapsulation of mammalian cells. We have characterized this system regarding capsule formation, strength and size of the capsules as well as viability of the cells after encapsulation. In addition, we demonstrate the efficacy of these capsules as a "microfactory" in vitro and in vivo. Using encapsulated hybridoma cells we were able to demonstrate long-term release of antibodies up to four months in vivo. In another application we could show the therapeutic relevance of encapsulated genetically modified cells as an in vivo activation center for cytostatic drugs during tumor therapy.

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“…In 1964, Chang wrapped tissue cells with a nylon semipermeable membrane that only allowed the passage of small molecules of nutrients, metabolites and secretions, while preventing the passage of macromolecular substances such as cells and antibodies (Figure C) . Chang subsequently showed that these semipermeable membranes could also encapsulate hemoglobin, enzymes, cells, microorganisms, adsorbents, magnetic materials and other bioactive substances. − Membranes protect bioactive substances inside artificial cells from direct contact with the outside environment and allow the entry and exit of smaller molecules, such as enzyme substrates, hormones, short peptides and small MW proteins. Therefore, the use of different types of membrane materials allows for the control of membrane permeability.…”

Section: Development Of Artificial Cellsmentioning

confidence: 99%

Artificial Cells: Past, Present and Future

Jiang

Zheng

et al. 2022

ACS Nano

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Artificial cells are constructed to imitate natural cells and allow researchers to explore biological process and the origin of life. The construction methods for artificial cells, through both top-down or bottom-up approaches, have achieved great progress over the past decades. Here we present a comprehensive overview on the development of artificial cells and their properties and applications. Artificial cells are derived from lipids, polymers, lipid/polymer hybrids, natural cell membranes, colloidosome, metal−organic frameworks and coacervates. They can be endowed with various functions through the incorporation of proteins and genes on the cell surface or encapsulated inside of the cells. These modulations determine the properties of artificial cells, including producing energy, cell growth, morphology change, division, transmembrane transport, environmental response, motility and chemotaxis. Multiple applications of these artificial cells are discussed here with a focus on therapeutic applications. Artificial cells are used as carriers for materials and information exchange and have been shown to function as targeted delivery systems of personalized drugs. Additionally, artificial cells can function to substitute for cells with impaired function. Enzyme therapy and immunotherapy using artificial cells have been an intense focus of research. Finally, prospects of future development of cell-mimic properties and broader applications are highlighted.

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Artificial Cells and Bioencapsulation in Bioartificial Organs^a

Cited by 17 publications

References 25 publications

Optimal Conditions of Transplantable Binary Polyelectrolyte Microcapsules

Optimal Conditions of Transplantable Binary Polyelectrolyte Microcapsules

Development of Cellulose Sulfate‐based Polyelectrolyte Complex Microcapsules for Medical Applications

Artificial Cells: Past, Present and Future

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Artificial Cells and Bioencapsulation in Bioartificial Organsa

Cited by 17 publications

References 25 publications

Optimal Conditions of Transplantable Binary Polyelectrolyte Microcapsules

Optimal Conditions of Transplantable Binary Polyelectrolyte Microcapsules

Development of Cellulose Sulfate‐based Polyelectrolyte Complex Microcapsules for Medical Applications

Artificial Cells: Past, Present and Future

Contact Info

Product

Resources

About

Artificial Cells and Bioencapsulation in Bioartificial Organs^a