Artificial hydrogenase: biomimetic approaches controlling active molecular catalysts

Experimental and DFT Investigations Reveal the Influence of the Outer Coordination Sphere on the Vibrational Spectra of Nickel-Substituted Rubredoxin, a Model Hydrogenase Enzyme

“…17–20 Many excellent reviews describing these compounds and highlighting progress towards increased activity have been written in recent years. 21–26 However, no single catalyst has been able to incorporate all of the unique features of the native H 2 ase enzymes.…”

Coordination complexes and biomolecules: A wise wedding for catalysis upgrade

“…The ultimate goal would be to select the crucial parameters for powerful catalysis, getting rid of the less pertinent ones. Such mimics (structural, functional or both) were thus developed for hydrogenases [1][2][3][4], superoxide dismutases [5][6][7][8][9], photosynthetic system [10,11], oxygenases [12] etc. These systems go from the simplest, using very usual metallic ions and ligands [13] to the most sophisticated ones [14][15][16].…”

Construction of a hybrid biocatalyst containing a covalently-linked terpyridine metal complex within a cavity of aponitrobindin

“…Development of a hybrid biocatalyst combining a metal complex and a protein scaffold is a worthy objective because the scaffold would be expected to provide a well-defined and tunable environment for the metal complex [1][2][3][4][5][6][7][8][9]. Over the last decade, enantio-or chemoselective hydrogenations, Diels-Alder reactions, oxidations, cyclopropanations, and hydrolysis reactions have been demonstrated to be promoted by a series of hybrid biocatalysts [10][11][12][13][14][15][16][17][18][19][20][21][22][23].…”