The metal oxide glasses have attracted huge interest as promising types of shielding materials to replace the toxic, heavy and costly conventional shielding materials. In this work, the physical and the shielding effectiveness of Tellurite glass sample (S1) contain host metal oxides (85TeO2-5Nb2O5-5ZnO-5Ag2O) were evaluatedatphoton energies range between 15keVand1MeV.The shielding parameters of the proposed glass system such as linear attenuation coefficients, HVL, MFP, Zeff, and Neffwere evaluated. The proposed samples showed a superior performance at the diagnostic energy range between 40 and 90 keV and a comparable shielding effectiveness above 90keV when compared with other commercial standard shielding materials.