The primary aims of this research paper involve the creation and verification of machine learning-based quality models that utilize Integrated Irrigation Water Quality Indices (IIGWQIs) through an integrated GIS approach. We utilize the Least-Squares Support Vector Machines (LS-SVM) and the Pearson Correlation Fuzzy Inference-based System (PC-FIS) to establish forecasts for groundwater quality in the Meknassy basin. This basin serves as a representative case of an irrigated region in a mining environment under arid climatic conditions in central Tunisia. The evaluated factors for groundwater quality encompass the Irrigation Water Quality Index (IWQIndex), Sodium Adsorption Ratio Index (SARIndex), Soluble Sodium Percentage Index (SSPIndex), Potential Salinity Index (PSIndex), Kelley Index (KIndex), and Residual Sodium Carbonate Index (RSCIndex). These factors were determined based on measurements from 53 groundwater wells, which included various physico-chemical parameters. The hydrogeochemical facies identified included Ca-Mg-SO4, mixed Ca-Mg-Cl-SO4, and Na-Cl facies, revealing processes such as carbonate weathering, carbonate dissolution, interactions between rocks and groundwater, and mixing ionic substitution. In terms of the irrigation suitability categories, the IWQIndex, SSPIndex, PSIndex, Kindex, and RSCIndex indicated no limitation or minimal limitation (77.36%), secure (92.45%), favorable to excellent (66.04%), favorable (81.13%), and average to secure (88.68%), respectively. However, only 15.09% were considered favorable, according to SARIndex. The evaluation of the predictive models revealed the effectiveness of both the PC-FIS model and the LS-SVM model in accurately forecasting the IIGWQIs.