Modernization and advancement in technology have developed a new field called Health Informatics. It is an interdisciplinary that accommodates bioinformatics, artificial intelligence (AI), and machine learning (ML) applications. Additionally, a large amount of data that travels around the global network of cloud computing has coined the term internet of things (IoT), which has fostered a new wave of innovation in the healthcare sector. This chapter provides insights into how recognition systems, self-monitoring systems, big data analysis and interpretation, etc. use AI and IoT-based models to accelerate the capabilities of providing advanced healthcare outcomes. It not only unlocks futuristic smart healthcare, but also platforms a revolutionary milestone in the medical world. Moreover, the chapter addresses the challenges of security, scalability, cost-effectiveness, standardization, and quality care encountered by the healthcare sector.