Putting AI at the centre of heart failure care Heart failure (HF) is a global pandemic affecting over 40 million people worldwide and imposing a considerable human and economic burden. 1-3 At least 1-2% of the global healthcare budget is spent on HF, costs driven primarily by hospitalizations, many of which are regarded as preventable. 3-5 Worryingly, the prevalence of HF is increasing substantially alongside increases in predisposing diseases and co-morbidities (i.e. diabetes, hypertension, and obesity), a growing 'Western lifestyle' in developing countries, and an ageing population worldwide, 1,6,7 together imposing unsustainable demands on our healthcare systems. A new vision of care is required, one that embraces digital technologies to drive fundamental change in HF healthcare. Artificial intelligence (AI), a rapidly evolving field in medicine, especially cardiology, is revolutionizing risk prediction and stratification, diagnostics, precision medicine, workflows, and efficiency. 8-10 In a strategic paper, we [PAtient Self-care uSing eHealth In chrONic Heart Failure (PASSION-HF) consortium] propose using digital therapeutics powered by AI as a personalized approach to HF self-care. 11 PASSION-HF aims to develop a virtual 'doctor at home' system. Being able to pool datasets smartly and extrapolating relevance at an individual level, our AI approach offers huge potential for reducing clinician burden, improving clinical efficacy, and enhancing patient experience and outcomes. 11 AI techniques are transforming cardiovascular diagnosis through interpreting and finding meaning in vast sets of data, faster and more effectively than the human brain. 8 Machine learning, the most common application of AI, is characterized by the ability to learn from data without being explicitly programmed. Through the development of reinforcement learning algorithms, machine learning recognizes patterns in new data to create its own logic to continuously improve cardiovascular disease prediction and diagnosis. 9 Accordingly, AI is able to deal with enormous combinations of multi-markers, essential in the prediction and prevention of deterioration of complex diseases like HF. Even so, such predictive models are largely dependent on high-quality large-scale datasets that are not easily accessible, and datasets of poorer quality may lead to biases with subsequent decrease in the predictive accuracy of models. 12 However, through strategic selection of underlying data and use of sensitivity checks, algorithm developers can mitigate AI bias. 12 This in itself accentuates