Artificial Muscles to Restore Transport Function of Diseased Atria

Tozzi, Piergiorgio; Hayoz, Daniel; Thévenaz, Pierrick; Roulet, Jean-Yves; Salchli, Francois; Segesser, Ludwig K. von

doi:10.1097/mat.0b013e3181612247

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…Similar to natural muscles, the nitinol fibres reduce their length when electrically stimulated; hence, the concept of motorless motion or artificial muscles. This concept, the technical characteristics of the device and the preliminary in vitro results have been extensively described in our previous publications [8,9].…”

Section: Description Of the Atrial Assist Devicementioning

confidence: 99%

Biometal muscle to restore atrial transport function in a permanent atrial fibrillation animal model: a potential tool in the treatment of end-stage heart failure

Tozzi¹,

Hayoz

Taub³

et al. 2010

European Journal of Cardio-Thoracic Surgery

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Section: Description Of the Atrial Assist Devicementioning

confidence: 99%

Biometal muscle to restore atrial transport function in a permanent atrial fibrillation animal model: a potential tool in the treatment of end-stage heart failure

Tozzi¹,

Hayoz

Taub³

et al. 2010

European Journal of Cardio-Thoracic Surgery

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“…Patients continue to require anticoagulation therapy for life and, thus are exposed to the risk of haemorrhagic complications. We first introduced the concept of an Atrial Assist Device and developed the related device called Atripump to definitely restore the pump function of the atrium in patients suffering of chronic AF [9][10][11][12]. Atripump is a dome shape silicone coated nitinol actuator 5 mm high, mounted on a plastic ring 55 mm in diameter.…”

Section: Figurementioning

confidence: 99%

Artificial muscle: the human chimera is the future

Tozzi¹

2011

Swiss Med Wkly

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Severe heart failure and cerebral stroke are broadly associated with the impairment of muscular function that conventional treatments struggle to restore. New technologies enable the construction of "smart" materials that could be of great help in treating diseases where the main problem is muscle weakness. These materials "behave" similarly to biological systems, because the material directly converts energy, for example electrical energy into movement. The extension and contraction occur silently like in natural muscles. The real challenge is to transfer this amazing technology into devices that restore or replace the mechanical function of failing muscle. Cardiac assist devices based on artificial muscle technology could envelope a weak heart and temporarily improve its systolic function, or, if placed on top of the atrium, restore the atrial kick in chronic atrial fibrillation. Artificial sphincters could be used to treat urinary incontinence after prostatectomy or faecal incontinence associated with stomas. Artificial muscles can restore the ability of patients with facial paralysis due to stroke or nerve injury to blink. Smart materials could be used to construct an artificial oesophagus including peristaltic movement and lower oesophageal sphincter function to replace the diseased oesophagus thereby avoiding the need for laparotomy to mobilise stomach or intestine. In conclusion, in the near future, smart devices will integrate with the human body to fill functional gaps due to organ failure, and so create a human chimera.

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Implantable Systems for Stress Urinary Incontinence

et al. 2017

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Stress urinary incontinence (SUI), the involuntary urine leakage due to failure of the urethral closure mechanism, is a global health challenge with substantial human suffering and socioeconomic costs. Approximately 167 million male and female patients are predicted to suffer from SUI in 2018, worldwide. A wide range of surgical interventions are available for the treatment of SUI. Severe cases, however, usually require the implantation of artificial urinary sphincter devices. This review comparatively presents and analyzes the working principles, as well as the challenges, associated with the current implantable SUI systems in clinical use. These include slings, urethral bulking agents, artificial urinary sphincters, and adjustable continence devices. It further reports on recent research progress and state-of-the-art in the field of SUI implants, including an original approach proposed by the authors with a pressure feedback sensory mechanism. The new emerging field of artificial muscle devices, including electroactive polymers, provides a promising innovative solution for replacing the weakened urethral sphincter in SUI patients.

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Artificial Muscles to Restore Transport Function of Diseased Atria

Cited by 5 publications

References 6 publications

Biometal muscle to restore atrial transport function in a permanent atrial fibrillation animal model: a potential tool in the treatment of end-stage heart failure

Biometal muscle to restore atrial transport function in a permanent atrial fibrillation animal model: a potential tool in the treatment of end-stage heart failure

Artificial muscle: the human chimera is the future

Implantable Systems for Stress Urinary Incontinence

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