The use of wastes as alternative fuel (AF) at the cement plants for clinkerization processes has increased in recent years as sustainable waste management. Such co-processing of AFs at cement plants causes some changes in the composition of the plant emissions, depending on waste type, kiln thermal power, thermal substitution rate, etc. Emissions of nitrogen oxides (NO x ) are among the major environmental concerns in these plants. The paper includes a modeling study of NO x emissions at a cement plant during the co-processing of AFs. Due to the nonlinear characteristic of the relationship between operational parameters and NO x emissions, the artificial neural network (ANN) approach was applied and studied. The study showed that NO x emissions can be predicted satisfactorily by using ANN at cement plants. Therefore, the model proposed may be used by cement plant operators to estimate their emission levels before starting the use of a new fuel source.