Interrupting, altering, or stealing autism-related sensitive data by cyber attackers is a lucrative business which is increasing in prevalence on a daily basis. Enhancing the security and privacy of autism data while adhering to the symmetric encryption concept is a critical challenge in the field of information security. To identify autism perfectly and for its data protection, the security and privacy of these data are pivotal concerns when transmitting information over the Internet. Consequently, researchers utilize software or hardware disk encryption, data backup, Data Encryption Standard (DES), TripleDES, Advanced Encryption Standard (AES), Rivest Cipher 4 (RC4), and others. Moreover, several studies employ k-anonymity and query to address security concerns, but these necessitate a significant amount of time and computational resources. Here, we proposed the sanitization approach for autism data security and privacy. During this sanitization process, sensitive data are concealed, which avoids the leakage of sensitive information. An optimal key was generated based on our improved meta-heuristic algorithmic framework called Enhanced Combined PSO-GWO (Particle Swarm Optimization-Grey Wolf Optimization) framework. Finally, we compared our simulation results with traditional algorithms, and it achieved increased output effectively. Therefore, this finding shows that data security and privacy in autism can be improved by enhancing an optimal key used in the data sanitization process to prevent unauthorized access to and misuse of data.