The potential is investigated of the generalized regression neural networks (GRNN) technique in modelling of reference evapotranspiration (ET 0 ) obtained using the FAO Penman-Monteith (PM) equation. Various combinations of daily climatic data, namely solar radiation, air temperature, relative humidity and wind speed, are used as inputs to the ANN so as to evaluate the degree of effect of each of these variables on ET 0 . In the first part of the study, a comparison is made between the estimates provided by the GRNN and those obtained by the Penman, Hargreaves and Ritchie methods as implemented by the California Irrigation Management System (CIMIS). The empirical models were calibrated using the standard FAO PM ET 0 values. The GRNN estimates are also compared with those of the calibrated models. Mean square error, mean absolute error and determination coefficient statistics are used as comparison criteria for the evaluation of the model performances. The GRNN technique (GRNN 1) whose inputs are solar radiation, air temperature, relative humidity and wind speed, gave mean square errors of 0.058 and 0.032 mm 2 day , and determination coefficients of 0.985 and 0.986 for the Pomona and Santa Monica stations (Los Angeles, USA), respectively. Based on the comparisons, it was found that the GRNN 1 model could be employed successfully in modelling the ET 0 process. The second part of the study investigates the potential of the GRNN and the empirical methods in ET 0 estimation using the nearby station data. Among the models, the calibrated Hargreaves was found to perform better than the others.