THE experiments described herein were carried out mainly to determine the effects on the C02 partial pressure in some of the tissues and body cavities, produced by changes of temperature, muscular exercise and artificial respiration.Prem?ous researches. The previous work on C02 partial pressure in tissues and body cavities is very extensive. Amongst the earliest researches are those of Davy(1) in 1823, on the C02 content in the gases in a case of pneumothorax and those of Leconte and Demarquay (2) in 1859 on the changes in C02 content in gases injected subcutaneously and into the peritoneal cavity. Attention will be directed here to some of the researches of physiological significance and of importance to the present work. In 1914 Webb, Gilbert, James and Havens(3) injected nitrogen into one side of the thoracic cavity of one monkey and a similar amount of air into one side of the thoracic cavity of another monkey of about the same size and weight, and found the C02 percentages to be 8-52 and 8-06 respectively after 48 hours. Rist and Strohl(4) concluded that there is a balance between the gases of a pneumothorax cavity and the gases in the venous blood; whilst Dautrebande and Spehl() pointed out that it was more correct to state that the composition of the gases was regulated by the blood bathing the compressed lung, this being richer in C02 than that of the normal lung, because of the lessened circulation due to the compression. Grass and Meiners(6) distinguished between an open and closed pneumothorax by drawing out some of the gas from the cavity. If there was an opening elsewhere communicating with the air, fresh air rushed in and thus lowered the C02 percentage. They also described a method to estimate the volume of gases in the thoracic cavity.Henderson and Haggard(7) injected air into the abdominal cavity of dogs under local anaesthesia and showed that the C02 tension in the abdominal air approximated in about one hour, to that in the arterial