Artificial (Pseudo)peptides for Molecular Recognition and Catalysis

Redox-Active Biomolecular Architectures and Self-Assembled Monolayers Based on a Cyclodecapeptide Regioselectively Addressable Functional Template

“…Incorporating metal complexes in a biological assembly is thus of the greatest interest since it produces redox-active biomaterials which may act as sensing and/or switching devices. − In this rapidly growing research area, amino acids or peptide−ferrocene conjugates have recently been the subject of intense investigations. , As a matter of fact, due to its unique structural and well behaved redox properties combined with an extensive chemical reactivity, the ferrocenyl group is undoubtly the most convenient building block for the construction of redox-responsive bioconjugates 15 and generally speaking to build selective receptors that can effectively convert a molecular recognition event into a physically measurable quantity, e.g., an electrochemical signal . Another crucial step toward electrochemical devices is the immobilization of redox chemosensors onto electrodes, which requires the introduction of suited functionality allowing electrode surface derivatization.…”