Artificial transmembrane potassium transporters: designs, functions, mechanisms and applications

Yuan, Xiyu; Shen, Jie; Zeng, Huaqiang

doi:10.1039/d3cc04488b

Chem. Commun.

2024

DOI: 10.1039/d3cc04488b

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Artificial transmembrane potassium transporters: designs, functions, mechanisms and applications

Xiyu Yuan,

Jie Shen,

Huaqiang Zeng

Abstract: In this review, we provide the very first comprehensive exposition of artificial potassium transporters developed mostly over the past ten years.

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Cited by 9 publications

References 97 publications

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Artificial Lithium Channels Built from Polymers with Intrinsic Microporosity

Gou,

Wang,

Yang

et al. 2024

Angewandte Chemie

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In sharp contrast to numerous artificial potassium channels developed over the past decade, the study of artificial lithium‐transporting channels has remained limited. We demonstrate here the use of an interesting class of polymers with intrinsic microporosity (PIM) for constructing artificial lithium channels. These PIM‐derived lithium channels show exceptionally efficient (γLi+ > 40 pS) and highly selective transport of Li+ ions, with selectivity factors of > 10 against both Na+ and K+. By simply adjusting the initial reaction temperature, we can tune the transport property in a way that PIMs synthesized at initial reaction temperatures of 60 °C and 80°C exhibit improved transport efficiency and selectivity, respectively, in the dioleoyl phosphatidylcholine membrane.

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Artificial Lithium Channels Built from Polymers with Intrinsic Microporosity

Gou,

Wang,

Yang

et al. 2024

Angewandte Chemie

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Engineered Reactive Oxygen Species (ROS)‐Responsive Artificial H⁺/Cl⁻ Ion Channels for Targeted Cancer Treatment

Jia,

Luo,

Zhou

et al. 2024

Angewandte Chemie

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Reactive oxygen species (ROS)‐responsive ion channels regulate the ion flow across the membranes in response to alterations in the cellular redox state, playing a crucial role in cellular adaptation to oxidative stress. Despite their significance, replicating ROS‐responsive functionality in artificial ion channels remains elusive. In this study, we introduce a novel class of artificial H+/Cl‐ ion channels activatable by elevated ROS levels in cancer cells. ROS‐induced decaging of the phenylboronate group triggers the rapid release of the channel‐forming units, leading to self‐assembly of the H‐bonded cascades facilitating the synergistic transport of H+ and Cl‐ ions, with H+/Cl‐ ion transport selectivity of 7.7. Upon activation, ROS‐C‐Cl exhibits significant apoptotic activity against human breast cancer cells, achieving an IC50 of 2.8 μM, comparable to that of paclitaxel. Exploiting the intrinsic oxidative microenvironment of cancer cells, along with the enhanced oxidative stress arising from H+/Cl‐ co‐transport, ROS‐C‐Cl demonstrates exceptional selectivity in targeting cancer cells with a selectivity index of 10.2 over normal breast cells, outperforming that of paclitaxel by 19.4 folds.

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Artificial Lithium Channels Built from Polymers with Intrinsic Microporosity

Gou,

Wang,

Yang

et al. 2024

Angew Chem Int Ed

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Artificial transmembrane potassium transporters: designs, functions, mechanisms and applications

Abstract: In this review, we provide the very first comprehensive exposition of artificial potassium transporters developed mostly over the past ten years.

Cited by 9 publications

References 97 publications

Artificial Lithium Channels Built from Polymers with Intrinsic Microporosity

Artificial Lithium Channels Built from Polymers with Intrinsic Microporosity

Engineered Reactive Oxygen Species (ROS)‐Responsive Artificial H⁺/Cl⁻ Ion Channels for Targeted Cancer Treatment

Artificial Lithium Channels Built from Polymers with Intrinsic Microporosity

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Artificial transmembrane potassium transporters: designs, functions, mechanisms and applications

Abstract: In this review, we provide the very first comprehensive exposition of artificial potassium transporters developed mostly over the past ten years.

Cited by 9 publications

References 97 publications

Artificial Lithium Channels Built from Polymers with Intrinsic Microporosity

Artificial Lithium Channels Built from Polymers with Intrinsic Microporosity

Engineered Reactive Oxygen Species (ROS)‐Responsive Artificial H+/Cl− Ion Channels for Targeted Cancer Treatment

Artificial Lithium Channels Built from Polymers with Intrinsic Microporosity

Contact Info

Product

Resources

About

Engineered Reactive Oxygen Species (ROS)‐Responsive Artificial H⁺/Cl⁻ Ion Channels for Targeted Cancer Treatment