Abstract. The hypersurface in C 3 with an isolated quasi-homogeneous elliptic singularity of type E r , r = 6, 7, 8, has a natural Poisson structure. We show that the family of del Pezzo surfaces of the corresponding type E r provides a semiuniversal Poisson deformation of that Poisson structure.We also construct a deformation-quantization of the coordinate ring of such a del Pezzo surface. To this end, we first deform the polynomial algebra C[x 1 , x 2 , x 3 ] to a noncommutative algebra with generators x 1 , x 2 , x 3 and the following three relations labeled by cyclic parmutations (i, j, k) of (1, 2, 3):This gives a family of Calabi-Yau algebras A t ( ) parametrized by a complex number t ∈ C × and a triple = ( 1 , 2 , 3 ) of polynomials of specifically chosen degrees.Our quantization of the coordinate ring of a del Pezzo surface is provided by noncommutative algebras of the form A t ( )/ , where ⊂ A t ( ) stands for the ideal generated by a central element which generates the center of the algebra A t ( ) if is generic enough.