This paper presents a comprehensive analysis of the issue of wastewater due to oil spills and pollution in the Niger Delta region of Nigeria, which has led to significant environmental and socioeconomic consequences for local communities. The study employed a secondary data collection approach, drawing on various sources, including published research articles, reports, official records, and satellite imagery. Through a systematic review and synthesis of the available literature, the paper identified key challenges, mitigation and remediation strategies, policy recommendations, and areas for future research. The findings of this study revealed that the existing regulatory framework has not been fully effective in preventing and addressing oil spills and pollution in the Niger Delta region due to factors such as weak enforcement, inadequate resources, and overlapping responsibilities among regulatory agencies. Moreover, existing measures for oil spill response, clean-up, compensation, and remediation have had limited success, leaving affected communities to continue suffering from the impacts of oil spills and pollution. The paper highlights the potential of innovative approaches and technologies, such as advanced oil spill detection and monitoring technologies, bioremediation, and renewable energy, to enhance the effectiveness of mitigation and remediation efforts. Furthermore, the study emphasizes the importance of collaboration and cooperation among various stakeholders, including government agencies, oil companies, local communities, civil society organizations, and international partners, in addressing the challenges posed by oil spills and pollution in the Niger Delta region. Based on the findings, the paper presents several policy recommendations, such as strengthening the regulatory framework, enhancing transparency and accountability, promoting community participation and empowerment, and encouraging investment in sustainable development and clean technologies. These recommendations aim to inform and inspire policymakers, practitioners, and stakeholders to develop and implement effective strategies for mitigating and remediating the adverse impacts of oil spills and pollution on the environment, local communities, and the Nigerian economy. Finally, the paper identified several areas for future research, including the effectiveness of specific regulatory tools and enforcement mechanisms, the long-term impacts of oil spills and pollution, the potential of emerging technologies, the role of corporate social responsibility initiatives, the impact of public awareness campaigns and educational programs, and the effectiveness of international partnerships and collaborations.