Artocarpus altilis heartwood extract protects skin against UVB in vitro and in vivo

Tiraravesit, Narisara; Yakaew, Swanya; Rukchay, Racharat; Luangbudnark, Witoo; Viennet, Céline; Humbert, Philippe; Viyoch, Jarupa

doi:10.1016/j.jep.2015.09.023

Cited by 22 publications

(32 citation statements)

References 46 publications

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“…As a result, we concluded that the inhibition of MMP-1 production and promotion of type-1 procollagen synthesis by SMGGT were superior to the effects of L -ascorbic acid and these effects were more prominent when UVB was exposed. Similar pattern was observed with other herbal extract in previous report [ 23 ]. Therefore, we measured the changes of MMP-1 and type-1 procollagen expression by the treatment of SMGGT water extract in both UVB-non-irradiated and UVB-irradiated group to confirm the effects in molecular level.…”

Section: Resultssupporting

confidence: 92%

Anti-wrinkle effects of Seungma-Galgeun-Tang as evidenced by the inhibition of matrix metalloproteinase-I production and the promotion of type-1 procollagen synthesis

Kim

Bang

Yun

et al. 2016

BMC Complement Altern Med

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BackgroundSeungma-Galgeun-Tang (SMGGT), a traditional herbal medicinal formula, has been used to treat various skin problems such as inflammation and rashes in Korean traditional medicine. In order to clarify the scientific evidence for the biological efficacy of SMGGT on the prevention of skin aging and in particular wrinkle formation, molecular anti-wrinkle parameters were evaluated in cultured human dermal fibroblasts.MethodsStandard SMGGT was prepared from KFDA-certified herbal medicines and the chemical fingerprint of SMGGT was verified by HPLC-ESI-MS to insure the quality of SMGGT. To evaluate the inhibitory effects of SMGGT on the synthesis of matrix metalloproteinase-1 (MMP-1) and type-1 procollagen, the content of MMP-1 and type-1 procollagen synthesizing enzymes in cultured human dermal fibroblasts were measured using an ELISA kit and Western Blot, respectively.ResultsThe treatment of SMGGT water extract significantly inhibited the production of MMP-1 and promoted type-1 procollagen synthesis concentration dependently.ConclusionsThese results suggest that SMGGT has the potential to prevent wrinkle formation by down-regulating MMP-1 and up-regulating type-1 procollagen in human dermal fibroblasts.

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Section: Resultssupporting

confidence: 92%

Anti-wrinkle effects of Seungma-Galgeun-Tang as evidenced by the inhibition of matrix metalloproteinase-I production and the promotion of type-1 procollagen synthesis

Kim

Bang

Yun

et al. 2016

BMC Complement Altern Med

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“…Further study is needed to confirm and elucidate the structure of the active antiinflammatory compound in A. altilis. [8][9][10][11][12][13] Conclusion A. altilis leaves extracts showed good antiinflammatory properties and has the potential for development of anti-inflammatory drug.…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Activity of Artocarpus altilis (Parkinson) Fosberg in Wistar Male Rats

Riasari

Nurlalela²,

Gumilang³

2019

Pharmacology and Clinical Pharmacy Research (PCPR) is an intern

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Inflammation is a local reaction in vascular tissue characterized by several symptoms, e.g., swelling, redness, and pain. Indonesia is one of the countries with high biodiversity, including traditional medicinal plants. Artocarpus altilis is one the plants that is widely used to treat inflammation. There is limited information on biological activity of A. altilis.This study was performed to evaluate anti-inflammatory properties of A. altilis detached and attached leaves in Wistar male rats. A. altilis was extracted using soxhlet method at 67.4 0C with methanol solvent. Inflammation was induced by the administration of carrageenan to the rats paw. Subsequently, the extract of A. altilis were orally administered. The edema were measured using plethysmometer for 6 hours. We found that there were differences in anti-inflammatory activity between detached and attached leaves. The inhibition of edema in attached leaves were 50% and 53.33% for the concentration of 50 mg and 100 mg, respectively. The greater inhibiton was observed in the detached leaves, with 73.33% and 76.67% inhibition, for the concentration of 50 mg and 100 mg, respectively. Nevertheless, the inhibition percentage was still below diclofenac sodium as a positive control (83.33%). In conclusion, A. altilis leaves extracts showed good anti-inflammatory properties and has the potential for development of anti-inflammatory drug. Keywords: Artocarpus altilis, carageenan, inflammation, edema

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“…One of the most important components isolated from A. communis is artocarpin (shown in Figure ) which has many bioactivities such as antibacterial (Dej‐Adisai, Meechai, Puripattanavong, & Kummee, ; Septama & Panichayupakaranant, , ; Walther et al, ), anti‐oxidation (Lan, Tzeng, Lin, Yen, & Ko, ), anti‐inflammatory (Han, Kang, Windono, Lee, & Seo, ) and anticancer (Hu et al, ; Tzeng et al, ). In addition, artocarpin prevented skin damage from UVB irradiation (Lee et al, ; Tiraravesit et al, ). Owing to its numerous pharmacological activities, artocarpin can be used together with other drugs for treating diseases.…”

Section: Introductionmentioning

confidence: 99%

Identification of cytochrome P450 isoforms involved in the metabolism of artocarpin and assessment of its drug–drug interaction

Liu

2018

Biomedical Chromatography

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Artocarpin isolated from an agricultural plant Artocarpus communis has shows anti-inflammation and anticancer activities. In this study, we utilized recombinant human UDP-glucuronosyltransferasesupersomes (UGTs) and human liver microsomes to explore its inhibitory effect on UGTs and cytochrome p450 enzymes (CYPs). Chemical inhibition studies and screening assays with recombinant human CYPs were used to identify if CYP isoform is involved in artocarpin metabolism. Artocarpin showed strong inhibition against UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B7, CYP2C8 and CYP3A4. In particular, artocarpin exhibited competitive inhibition against CYP3A4 and noncompetitive inhibition against UGT1A3 and UGT1A7. The half inhibition concentration values for CYP3A4, UGT1A3 and UGT1A7 were 4.67, 3.82 and 4.82 μm, and the inhibition kinetic parameters for them were 0.78, 2.67 and 3.14 μm, respectively. After artocarpin was incubated in human liver microsomes and determined by HPLC, we observed its main metabolites (M1 and M2). In addition, we proved that CYP2D6 played the key role in the biotransformation of artocarpin in human liver microsomes. The result of molecular docking further confirmed that artocarpin interacted with CYP2D6, CYP2C8 and CYP3A4 through hydrogen bonds. This study provided preliminary results for further research on artocarpin or artocarpin-containing herbs.

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Artocarpus altilis heartwood extract protects skin against UVB in vitro and in vivo

Cited by 22 publications

References 46 publications

Anti-wrinkle effects of Seungma-Galgeun-Tang as evidenced by the inhibition of matrix metalloproteinase-I production and the promotion of type-1 procollagen synthesis

Anti-wrinkle effects of Seungma-Galgeun-Tang as evidenced by the inhibition of matrix metalloproteinase-I production and the promotion of type-1 procollagen synthesis

Anti-Inflammatory Activity of Artocarpus altilis (Parkinson) Fosberg in Wistar Male Rats

Identification of cytochrome P450 isoforms involved in the metabolism of artocarpin and assessment of its drug–drug interaction

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