In order to identify one system (module) in an interconnected dynamic network, one typically has to solve a Multi-Input-Single-Output (MISO) identification problem that requires identification of all modules in the MISO setup. For application of a parametric identification method this would require estimating a large number of parameters, as well as an appropriate model order selection step for a possibly large scale MISO problem, thereby increasing the computational complexity of the identification algorithm to levels that are beyond feasibility. An alternative identification approach is presented employing regularized kernel-based methods. Keeping a parametric model for the module of interest, we model the impulse response of the remaining modules in the MISO structure as zero mean Gaussian processes (GP) with a covariance matrix (kernel) given by the first-order stable spline kernel, accounting for the noise model affecting the output of the target module and also for possible instability of systems in the MISO setup. Using an Empirical Bayes (EB) approach the target module parameters are estimated through an Expectation-Maximization (EM) algorithm with a substantially reduced computational complexity, while avoiding extensive model structure selection. Numerical simulations illustrate the potentials of the introduced method in comparison with the state-of-the-art techniques for local module identification.