Aryl chlorothionoformate: A new versatile reagent for the preparation of nitriles and isonitriles under mild conditions

Evaluation of Electronic Effects in the Solvolyses of p‐Methylphenyl and p‐Chlorophenyl Chlorothionoformate Esters

“…Chlorothionofomate esters are useful as derivatizing agents [1] and common organic building blocks in the synthesis of commercial thiocarbonate esters, nitriles, and isonitriles [2,3]. High fungicidal activity was demonstrated [4] for the p -substituted aryl thiocarbamate analogs which are also cytotoxic [5].…”

Indirect evidences of desulfurization of a thiosemicarbazonecopper(II) system in aqueous basic medium

“…have been described in the literature. Some of them require basic reactives and lead to the attainment of carbonitriles [26] and carbodiimides [27][28][29][30][31]. In some cases, the attack of a basic reactive as sodium methoxide to the thioamide carbon atom has been proposed [32].…”

Copper-Catalyzed Dehydration of Primary Amides to Nitriles

“…Up to now manifold syntheses have been established to access nitriles. Among those protocols the dehydration of amides is an attractive approach and diverse reagent to perform this reaction have been introduced [2][3][4][5][6][7][8][9][10][11][12][13][14][15]. However, the application of stoichiometric amounts of highly acidic and basic compounds disfavors the dehydration of sensitive substrate and reduces the generality of the methods.…”