Aryl hydrocarbon receptor-mediated induction of microsomal drug-metabolizing enzyme activity by indirubin and indigo

Sugihara, Kazumi; Kawa, Shigeyuki; Yamada, Tsuyoshi; Okayama, Takashige; Ohta, Shigeru; Yamashita, Keisuke; Yasuda, Mineo; Fujii‐Kuriyama, Yoshiaki; Saeki, Ken'ich; Matsui, Saburo; Matsuda, Tomonari

doi:10.1016/j.bbrc.2004.04.066

Cited by 66 publications

(43 citation statements)

References 28 publications

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“…Antitumor activity of 7-bromoindirubin-3 0 -oxime J Ribas et al (Adachi et al, 2001;Spink et al, 2003;Knockaert et al, 2004;Sugihara et al, 2004). 7-Bromoindirubin-3 0 -oxime clearly activates AhR as observed in an in vitro luciferase reporter system (unpublished), and confirmed by the AhR-dependent expression of p27…”

Section: Discussionmentioning

confidence: 82%

7-Bromoindirubin-3′-oxime induces caspase-independent cell death

Ribas

Bettayeb²,

Ferandin³

et al. 2006

Oncogene

102

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Section: Discussionmentioning

confidence: 82%

7-Bromoindirubin-3′-oxime induces caspase-independent cell death

Ribas

Bettayeb²,

Ferandin³

et al. 2006

Oncogene

102

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“…Indigo and indirubin have been identified in human urine and found to be potent activators of AHR (Adachi et al, 2001;Peter Guengerich et al, 2004;Sugihara et al, 2004). Indirubin was found to be a more potent human AHR agonist when compared with the murine Ah b-1 allele (high affinity for TCDD) of the receptor .…”

Section: Host Metabolism Of Indolesmentioning

confidence: 99%

Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation

Hubbard¹,

Murray²,

Perdew³

2015

Drug Metab Dispos

488

432

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The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor recognized for its role in xenobiotic metabolism. The physiologic function of AHR has expanded to include roles in immune regulation, organogenesis, mucosal barrier function, and the cell cycle. These functions are likely dependent upon ligandmediated activation of the receptor. High-affinity ligands of AHR have been classically defined as xenobiotics, such as polychlorinated biphenyls and dioxins. Identification of endogenous AHR ligands is key to understanding the physiologic functions of this enigmatic receptor. Metabolic pathways targeting the amino acid tryptophan and indole can lead to a myriad of metabolites, some of which are AHR ligands. Many of these ligands exhibit species selective preferential binding to AHR. The discovery of specific tryptophan metabolites as AHR ligands may provide insight concerning where AHR is activated in an organism, such as at the site of inflammation and within the intestinal tract.

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“…Indirubin and its derivatives bind to and inhibit cyclin-dependent kinase (CDK) 3 1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25, displaying potent growth inhibitory effects in various human tumors (9 -12). Additionally, indirubin derivatives bind to and inhibit glycogen synthase kinase-3␤ (13)(14)(15), c-Src kinase (16), aryl hydrocarbon receptor (17,18), and rabbit muscle glycogen phosphorylase b (19). More recently indirubin was shown to inhibit c-Jun NH 2 -terminal kinase (20).…”

mentioning

confidence: 99%