Prostaglandins, Leukotrienes, and Lipoxins 1985
DOI: 10.1007/978-1-4684-4946-4_60
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Arylmethyl Phenyl Ethers

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Cited by 20 publications
(5 citation statements)
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“…3) and longer (up to 24 h, Fig. 4) incubations of iron-binding HP-4-ones with sbLPO show similar degrees of inhibition to cellular 5-LPO, contrasting with known translocation inhibitors, which are considerably less active in cell-free compared with the cellular systems (37,40). Translocation-type inhibition is unlikely to be a major mechanism with iron chelators but could account for some of the effects of Ome-25.…”
Section: Discussionmentioning
confidence: 71%
“…3) and longer (up to 24 h, Fig. 4) incubations of iron-binding HP-4-ones with sbLPO show similar degrees of inhibition to cellular 5-LPO, contrasting with known translocation inhibitors, which are considerably less active in cell-free compared with the cellular systems (37,40). Translocation-type inhibition is unlikely to be a major mechanism with iron chelators but could account for some of the effects of Ome-25.…”
Section: Discussionmentioning
confidence: 71%
“…The cyclo-oxygenase inhibitors, indomethacin and flurbiprofen, inhibited arachidonic acid-induced plasma extravasation but less effectively than the 5-lipoxygenase inhibitors, quercetin and NDGA. AA861 and REV5901 which have been shown to be selective 5-lipoxygenase inhibitors (Ashida et al, 1982;Coutts et al, 1985) were also inhibitory. Although REV5901 caused a concentration-dependent inhibition of arachidonic acid-induced plasma extravasation it had no statistically a) 100- Drug concentration (,ug per site) Figure 5 The effect of mixed cyclo-oxygenase and lipoxygenase inhibitors on arachidonic acid-induced inflammation in rabbit skin: phenidone (0); BW755C (0).…”
Section: Pharmacological Modulationmentioning
confidence: 98%
“…The positional isomers 96 and 45 were prepared and found to inhibit 5-LO LTD 4 receptor [82]. Compounds 97 and 98 were derived from 96 [83]. Compound 99 was prepared by Wyeth-Ayerst by incorporating quinolylmethyloxy pharmacophore to the effective compound 78; it was active, but showed significant mutagenicity [61].…”
Section: Compounds With Dual Activitymentioning
confidence: 99%