AS-167: Drug-Eluting Stents in the Treatment of In-Stent Restenosis

Cherian, S.; Sebastian, Cherian; Puri, Aniket; Liang, Michael; Ten, Yuli; Devlin, Gerard

doi:10.1016/j.amjcard.2010.01.214

Cited by 1 publication

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“…146 Many drugs have been used to treat ISR resulting from DES. 147 Accordingly, to prevent the recurrence of stenosis and to ensure enduring clinical success, these drugs should exert the following effects: (i) to only inhibit vascular SMC proliferation and migration, (ii) to repair anatomical and functional endothelial integrity, (iii) to decrease the risk of ST, and (iv) to decrease inflammation, especially for coatings with proinflammatory components. 148 The drugs that are currently used to modify DES or that are being tested for this purpose are described in Table III.…”

Section: Surface Modifications Of Stents For Promoting Antirestenosismentioning

confidence: 99%

Surface modification of implanted cardiovascular metal stents: From antithrombosis and antirestenosis to endothelialization

Zhang

Liu

et al. 2013

J Biomedical Materials Res

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Driven by the complications occurring with bare metal stents and drug-eluting stents, concerns have been raised over strategies for long-term safety, with respect to preventing or inhibiting stent thrombosis, restenosis, and in-stent restenosis in particularly. Surface modification is very important in constructing a buffer layer at the interface of the organic and inorganic materials and in ultimately obtaining long-term biocompatibility. In this review, we summarize the developments in surface modification of implanted cardiovascular metal stents. This review focuses on the modification of metal stents via coating drugs or biomolecules to enhance antithrombosis, antirestenosis, and/or endothelialization. In addition, we indicate the probable future work involving the modification of the metallic blood-contacting surfaces of stents and other cardiovascular devices that are under development.

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Section: Surface Modifications Of Stents For Promoting Antirestenosismentioning

confidence: 99%