AS-OCT and Ocular Hygrometer as Innovative Tools in Dry Eye Disease Diagnosis

Gaudenzi, Daniele; Mori, Tommaso; Crugliano, Salvatore; Grasso, Antonella; Frontini, Carlo; Carducci, Antonella; Yadav, Siddharth; Sgrulletta, Roberto; Schena, Emiliano; Coassin, Marco; Zazzo, Antonio Di

doi:10.3390/app12031647

Cited by 6 publications

(9 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using DEvice©, patients with DED showed statistically significant higher values of RH compared to the control group. These results were consistent with data reported in a small observational pilot study, in which this tool was utilized to measure the fluctuation in relative humidity by analyzing the curvature shape, the speed of changes, and the ultimate RH after one minute [20]. Conversely, no statistically significant differences were detected for the mean values of temperature between the two groups.…”

Section: Discussionsupporting

confidence: 90%

“…Thirty minutes after the Keratograph assessment, all patients and controls were examined by means of DEvice© (AI, Rome, Italy), which allowed the measurement of RH and temperature in a closed microenvironment around the ocular surface. Technical details of the instrument along with its modality of use have been previously described [ 20 ]. Briefly, the DEvice© was positioned by the operator on the orbital margins of the patient, who was asked to avoid blinking during the assessment period ( Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%

“…It is positioned within a cup and with the entire ocular surface system, comprising the enclosed environment where the measurements are conducted. A previous observational pilot study showed higher RH values in a small sample of patients with DED when compared to healthy controls [ 20 ]. The aim of the present study was to employ DEvice© for discriminating patients affected by DED from healthy subjects and to calculate its diagnostic accuracy for DED screening.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Novel Noninvasive Screening Tool for Dry Eye Disease

Vaccaro,

Borselli,

Scalia

et al. 2024

Diagnostics

View full text Add to dashboard Cite

Purpose: To assess the feasibility and the diagnostic accuracy of the new tool, DEvice© (AI, Rome, Italy), for screening patients with dry eye disease (DED). Methods: This study was performed at the University Magna Græcia of Catanzaro. Enrolled patients were classified as affected by DED (group 1) or not (group 2) using an already validated tool (Keratograph 5M, Oculus, Germany), evaluating the noninvasive keratograph breakup time (NIKBUT), tear meniscus height (TMH), meibomian gland loss (MGL), and bulbar redness. All the patients were then examined by means of DEvice©, which allowed the measurement of the relative humidity (RH) and temperature of the ocular surface. Symptoms were scored using the Ocular Surface Disease Index (OSDI) questionnaire. Results: Overall, 40 patients (17 males and 23 females, mean age 38.0 ± 17.1 years) were included: of these, 20 belonged to group 1 and the remaining 20 to group 2. Using Keratograph 5M, significant differences between groups 1 and 2 were detected for NIKBUT-first (respectively, 4.97 ± 1.85 vs. 13.95 ± 4.8 s; p < 0.0001) and for NIKBUT-average (10.55 ± 4.39 vs. 15.96 ± 4.08 s; p = 0.0003). No statistically significant changes were detected for TMH (p = 0.565), MGL (p = 0.051), and bulbar redness (p = 0.687). Using Device©, a statistically significant higher value of RH was found in group 1 compared to group 2 (respectively, 85.93 ± 10.63 vs. 73.05 ± 12.84%; p = 0.0049). A statistically significant correlation was found between RH and OSDI (r = 0.406; p = 0.009). The value RH showed a discriminating power to detect DED with an AUC = 0.782 (standard error 0.07264; 95% CI 0.6401–0.9249; p = 0.0022). Conclusions: The DEvice© can effectively discriminate DED patients from healthy subjects. The parameter RH showed good sensitivity, making this tool ideal for a fast and noninvasive DED screening.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Novel Noninvasive Screening Tool for Dry Eye Disease

Vaccaro,

Borselli,

Scalia

et al. 2024

Diagnostics

View full text Add to dashboard Cite

show abstract

“…Measuring the tear water evaporation rate at the time of diagnosis and during the course of the disease makes it possible to monitor the risk of a worsening ocular surface system, suggest an appropriate therapeutic approach, and check the efficacy of the chosen treatment [ 100 , 101 ].…”

Section: Clinical Picturementioning

confidence: 99%

One Soul and Several Faces of Evaporative Dry Eye Disease

Di Zazzo,

Barabino,

Fasciani

et al. 2024

JCM

Self Cite

View full text Add to dashboard Cite

The ocular surface system interacts with, reacts with, and adapts to the daily continuous insults, trauma, and stimuli caused by direct exposure to the atmosphere and environment. Several tissue and para-inflammatory mechanisms interact to guarantee such an ultimate function, hence maintaining its healthy homeostatic equilibrium. Evaporation seriously affects the homeostasis of the system, thereby becoming a critical trigger in the pathogenesis of the vicious cycle of dry eye disease (DED). Tear film lipid composition, distribution, spreading, and efficiency are crucial factors in controlling water evaporation, and are involved in the onset of the hyperosmolar and inflammatory cascades of DED. The structure of tear film lipids, and subsequently the tear film, have a considerable impact on tears’ properties and main functions, leading to a peculiar clinical picture and specific management.

show abstract

“…To overcome these issues, recent non-invasive devices have been developed to measure various novel diagnostic parameters, such as non-invasive break-up time, tear meniscus height, infrared meibography, aberrometry, tear film interferometry, humidity, temperature and corneal nerves metrics [5][6][7][8][9][10]. All-in-one integrate devices combining multiple tests to obtain a comprehensive ocular surface evaluation are now available.…”

mentioning

confidence: 99%