As time goes by … Would CD4+ T cells depletion induce early immunosenescence in HIV infected patients?

HIV Infection-Related Premature Immunosenescence: High Rates of Immune Exhaustion After Short Time of Infection

“…Alongside, a high parallelism between CMV and HIV-infections, including CMV-reactivation in HIV-infected patients [6], has been found. Both processes, HIV and CMV-infection, induce aberrant activation rates and continuous T-cell proliferation, putting HIV infection forward as an appeal model of premature immunosenescence [7]. Premature immunosenescence has been associated to a faster AIDS progression: during the first year under highly active antiretroviral therapy (HAART), HIV-infected patients gain 35 CD4 T cells less every 10 years of chronological age [8].…”

“…Immunosenescence has been reported in different HIV scenarios: acute HIV infection [6], HAART-treated individuals [6,7,11], virological failure and structured treatment interruptions [12], children [13] or patients with low level of CD4 T-cell repopulation [14]. When comparing HIV-infected patients' premature immunosenescence with healthy aging, cellular phenotypes are similar in HAART-*Address correspondence to this author at the Laboratory of Immunovirology, Service of Infectious Diseases, Virgen del Rocío University Hospital, Avda.…”