Asbestos and Mesothelioma

Godwin, Melvin Crawford; Jagatic, George

doi:10.1001/jama.1968.03140240065025

Cited by 14 publications

(12 citation statements)

References 4 publications

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“…25 Asbestos bodies have also been documented in hilar, mediastinal and abdominal lymph nodes, peritoneal mesotheliomatous tissue, and intestinal wall taken from mesothelioma cases. 13 On the level of electron microscopy, in 1973, LeBouffant et al 16 revealed the presence of numerous uncoated short, thin chrysotile fibers in pleural hyaline plaques taken from asbestos workers using a transmission electron microscope. This was an important finding at that time because pathologists could not obviously iden- tify coated or uncoated asbestos fibers in the hyaline plaque in routine histopathological slides under light microscopy although they knew that this unique pleural change was intimately related to exposure to asbestos.…”

Section: Discussionmentioning

confidence: 99%

“…Some inhaled asbestos fibers translocate from lung into regional lymph nodes, [13][14][15] pleural and peritoneal mesothelial tissues, [16][17][18][19][20][21][22][23][24] and other organs. 13,25 Fibers may pass from lung to other organs by direct migration 26,27 via lymphatic capillary system, [13][14][15]19 and by hematogenous spread. 28,29 Up to now, most investigators have focused exclusively on asbestos fibers in the lung for identification of asbestos fibers that contribute to induction of human malignant mesothelioma.…”

Section: Introductionmentioning

confidence: 99%

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Asbestos Fibers Contributing to the Induction of Human Malignant Mesothelioma

Suzuki

Yuen

2002

Annals of the New York Academy of Sciences

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To elucidate the features of the asbestos fibers contributing to the induction of human malignant mesothelioma, we used high-resolution analytical electron microscopy to determine the type, number, and dimensions of asbestos fibers in lung and mesothelial tissues in 168 cases of mesothelioma. Results: 1. Asbestos fibers were present in almost all of the lung and mesothelial tissues from the mesothelioma cases. 2. The most common types of asbestos fibers in lung were either an admixture of chrysotile with amphiboles, amphibole alone, and occasionally chrysotile alone. In mesothelial tissues, most asbestos fibers were chrysotile. 3. In lung, amosite fibers were greatest in number followed by chrysotile, crocidolite, tremolite/actinolite, and anthophyllite. In mesothelial tissues, chrysotile fibers were 30.3 times more common than amphiboles. 4. In some mesothelioma cases, the only asbestos fibers detected in either lung or mesothelial tissue were chrysotile fibers. 5. The average number of asbestos fibers in both lung and mesothelial tissues was two orders of magnitude greater than the number found in the general population. 6. The majority of asbestos fibers in lung and mesothelial tissues were shorter than 5 µm in length. Conclusions: 1) Fiber analysis of both lung and mesothelial tissues must be done to determine the types of asbestos fibers associated with the induction of human malignant mesothelioma; 2) short, thin asbestos fibers should be included in the list of fiber types contributing to the induction of human malignant mesothelioma; 3) Results support the induction of human malignant mesothelioma by chrysotile.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Asbestos Fibers Contributing to the Induction of Human Malignant Mesothelioma

Suzuki

Yuen

2002

Annals of the New York Academy of Sciences

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“…It is also known that asbestos fibers are capable of translocating from the lung into other tissues including lymph nodes and mesothelial tissue [3][4][5][6][7] . There were reports that asbestos bodies were found in various organs other than the lung, supporting that asbestos fibers were disseminated from the lung to other organs 8,9) . Asbestos fibers in human tissues can be identified and characterized by a high resolution analytical electron microscope, even if they are short and thin in dimension (≥0.1 µm in length and ≥0.03 µm in width).…”

Section: Introductionmentioning

confidence: 92%

“…It has been generally accepted that like other asbestos types, chrysotile fibers are capable of inducing human malignant mesothelioma [25][26][27][28] . This conclusion has been obtained from various sources including molecular biological studies [29][30][31][32][33] , animal experiments 2,15,[34][35][36][37][38] , epidemiological studies [39][40][41][42][43][44] , case reports [45][46][47][48] , and asbestos tissue burden studies 6,20) . The present study on asbestos tissue burden further supports the evidence that chrysotile fibers were capable of inducing human malignant mesothelioma, since a) chrysotile was the most common asbestos type seen in the mesothelial tissues which is the original site of the induction of mesothelioma and b) chrysotile was exclusively seen in both the lung and the mesothelial tissues in 15/64 (23.3%) cases, in the lung tissue alone in10/43 (23.3%) and in the mesothelial tissues alone in 30/44 (68.2%) cases.…”

Section: Commentsmentioning

confidence: 99%

Asbestos Tissue Burden Study on Human Malignant Mesothelioma.

Suzuki

Yuen

2001

INDUSTRIAL HEALTH

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Asbestos fibers in the lung and mesothelial tissues (mesotheliomatous tissue and hyaline plaque) taken from 151 human malignant mesothelioma cases were identified and characterized by high resolution analytical electron microscopy. Asbestos fibers were present in almost all of the lung tissue as well as in the mesothelial tissue. The most common asbestos types seen in the lung were an admixture of chrysotile with amphiboles followed by amphiboles alone and chrysotile alone. The majority of asbestos types seen in the mesothelial tissues were chrysotile alone, followed by chrysotile plus amphibole and amphibole alone. A disproportion of asbestos types between the lung and mesothelial tissues was frequently observed. The most common pattern of the disproportion was chrysotile plus amphibole(s) in the lung and chrysotile only in the mesothelial tissues, followed by amphibole(s) in the lung and chrysotile only in the mesothelial tissues. Such a disproportion was considered to have been caused by chrysotile fiber's strong capacity to translocate from the lung to mesothelial tissues. The number of asbestos fibers in the lung was 456.4 × × × × × 10 6 fibers/dry gram in maximum, 0.08 × × × × × 10 6 fibers/dry gram in minimum and 105 × × × × × 10 6 fibers/dry gram on average; in the mesothelial tissues it was 240.0 × × × × × 10 6 fibers/dry gram in maximum, 0.03 × × × × × 10 6 fibers/dry gram in minimum and 49.84 × × × × × 10 6 fibers/dry gram on average. These numbers were greater than those seen in the general population. The majority of asbestos fibers detected in the lung and mesothelial tissues were shorter than 5 µm in length. Asbestos fibers fit to Stanton's hypothetical dimensions (≥8.0 µm in length and ≤0.25 µm in diameter) were only 4.0%, since the majority of these fibers were shorter (<8 µm) and thinner (<0.25 µm) fibers. We concluded that such short, thin asbestos fibers should not be excluded from those contributing to the induction of human malignant mesothelioma. The present study supports that chrysotile asbestos can induce human malignant mesothelioma, since, in some of the mesothelioma cases, asbestos fibers detected in both the lung and mesothelial tissues, or lung tissue alone or mesothelial tissues alone were exclusively chrysotile fibers.

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“…Vianna and Polan [1978] reported two mesotheliomas in women whose husbands had exposure to brake linings, and one woman who was a textile worker and whose husband was a brake lining worker. Godwin and Jagatic [1968] reported two cases of mesothelioma, one in a 43-year-old woman, with peritoneal mesothelioma, who had spent 3 years weaving brake linings made of chrysotile asbestos and the second in a 50-year-old man who worked 5 years in a Canadian asbestos mine who gave X-ray diffraction evidence of only chrysotile present in his body.…”

Section: Evidence Of Disease In Persons Exposed To Asbestos From Brakesmentioning

confidence: 99%

Asbestos in brakes: Exposure and risk of disease

Lemen¹

2004

American J Industrial Med

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Asbestos has been incorporated into friction products since the early 1900s. Epidemiological studies have been equivocal in their analysis of the incidence of disease among mechanics servicing brakes. Decomposition of asbestos occurs during the normal usage of the brake due to thermal decomposition into forsterite, although not all asbestos is so converted. Short fibers, below 5 microm in length, are also found in brake products. Several facts are discussed including the toxicity of the remaining asbestos fibers, short asbestos fibers, and the health implications of exposure to forsterite. Control methodologies, when used appropriately, have reduced exposure to asbestos during brake servicing, but have not been able to entirely eliminate exposure to asbestos, thus bring into question the controlled use of asbestos for friction product such as brakes. Even the so called "controlled" use of asbestos containing brakes poses a health risk to workers, users, and their families.

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Asbestos and Mesothelioma

Cited by 14 publications

References 4 publications

Asbestos Fibers Contributing to the Induction of Human Malignant Mesothelioma

Asbestos Fibers Contributing to the Induction of Human Malignant Mesothelioma

Asbestos Tissue Burden Study on Human Malignant Mesothelioma.

Asbestos in brakes: Exposure and risk of disease

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