Asbestos, asbestosis, pleural plaques and lung cancer

Hillerdal, Gunnar; Henderson, Douglas W.

doi:10.5271/sjweh.186

Cited by 122 publications

(91 citation statements)

References 121 publications

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“…Plaques indicate consistent exposure to low fibre concentrations (0.19 fibre-years/ml) (40). Other potential pleural responses include lymph node calcification and carcinogenesis (41,42). The results of the current study are consistent with those of other studies, which reported that, in cases of chest wall pleural plaques detected in asbestos-exposed construction workers, ~70% exhibit lesions on both sides of the chest (20,39,43), and ~30% also exhibit calcifications (25% in the current sample) (20,39).…”

Section: Risk Indicators --------------------------------------------mentioning

confidence: 99%

“…Subjects with pleural plaques are at greater risk of lung cancer and malignant pleural mesothelioma, compared with the general population (38,41,42,44). Inhalation of asbestos fibres may induce two types of interconnected pathogenic processes involving the respiratory apparatus: Chronic inflammation or carcinogenesis.…”

Section: Risk Indicators --------------------------------------------mentioning

confidence: 99%

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Detection of pleural plaques in workers exposed to inhalation of natural fluoro-edenite fibres

et al. 2015

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Abstract. Fluoro-edenite is a natural mineral species initially isolated in Biancavilla, Sicily. The fibres are similar in size and morphology to certain amphibolic asbestos fibres, the inhalation of which may cause chronic inflammation and cancer. Occupational asbestos exposure is known to be associated with pleural and lung diseases, including pleural plaques. The aim of this study was to report the pleural and lung parenchymal lesions detected by high-resolution computed tomography (HRCT) in a group of construction workers exposed to fluoro-edenite. Information regarding life habits and occupational history was collected from 43 workers enrolled into the study. The participants underwent physical examination, blood analysis, search for uncoated fibres and ferruginous bodies in the sputum, pulmonary function tests, including diffusion capacity for carbon monoxide (TL CO ), and HRCT chest imaging. A general descriptive outcome analysis was also conducted; a prevalence ratio (PR) with 95% confidence interval and a two-tailed test P-value were calculated for pleural plaques using log-binomial regression, measuring plaque size and thickness, and cumulative exposure index (CEI). The mean values of the functional respiratory tests were within the normal range for all participants. A restrictive ventilatory defect was identified in two (5%) subjects and an obstructive ventilatory defect in three (7%) subjects. TL CO was reduced in two additional participants. Fibres were detected in 19 (44%) of subjects. Pleural involvement was documented in 39 (91%) workers, of whom 31 (72%) had bilateral plaques. Calcifications were detected in 25 (58%) of these participants. PR indicated a progressive increase in the risk of developing pleural lesions with rising CEI, i.e. length of exposure. The present findings demonstrate for the first time the presence of pleural plaques in the lungs of subjects exposed to fluoro-edenite fibres, and not to asbestos, through residing in Biancavilla and through their occupation.

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Section: Risk Indicators --------------------------------------------mentioning

confidence: 99%

Section: Risk Indicators --------------------------------------------mentioning

confidence: 99%

Detection of pleural plaques in workers exposed to inhalation of natural fluoro-edenite fibres

et al. 2015

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“…Patients with pleural plaques are at greater risk of asbestosis and should be monitored for such [52,58,59]. Although pleural plaques are benign, their presence is an indicator of risk of mesothelioma development [52], possibly associated with greater burden of asbestos exposure or retention [60,61].…”

Section: Pleural Thickeningmentioning

confidence: 99%

Management options for the complicated pleural space

Hsia

Musani

2013

Curr Respir Care Rep

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Clinicians frequently encounter patients with malignant and benign diseases involving the pleural space.Complications from these disease processes pose clinical challenges that often require a multi-disciplinary management approach. Here we discuss therapeutic options available for complicated diseases of the pleural space, including loculated malignant effusions, complicated pleural infections, hemothorax, nonexpanding lung, pleural thickening, and persistent bronchopleural fistulas. Our objective is to review current literature on management of these complex issues.

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“…Otros datos radiológicos que ayudan a distinguirla de otro tipo de lesiones especialmente tumorales, son la forma en cuña o redondeada, el engrosamiento pleural asociado y la pérdida de volumen del lóbu-lo restante. Aunque teóricamente se puede ver en fibrosis pleurales de cualquier origen, en la práctica la mayoría de los casos están asociados a fibrosis pleural secundaria a exposición al asbesto 8 ya sea en forma de fibrosis pleural difusa o de placas pleurales extensas y abigarradas. Es una entidad bastante infrecuente.…”

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Enfermedades pleurales benignas inducidas por asbesto

Boldú

Eguía

2005

Anales Sis San Navarra

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RESUMENLa exposición al asbesto es una causa importante de patología pleural y se puede producir con intensidades moderadas o ligeras dada la capacidad del asbesto de concentrarse en la pleura. Ello motiva junto a la prolongada latencia existente entre la exposición y la enfermedad, que sigamos viendo durante muchos años manifestaciones clínicas pleurales de exposición previa, a pesar del uso del asbesto cada vez más limitado en las últimas décadas. Dicha exposición puede presentarse con distintas manifestaciones tanto malignas como el mesotelioma como benignas, siendo las principales de éstas el derrame pleural benigno, las placas pleurales, la fibrosis pleural difusa y la atelectasia redonda.Palabras clave. Asbesto. Pleura. Benigna. ABSTRACTExposure to asbestos is an important cause of pleural pathology and can be produced with light or moderate tendencies given the capacity of asbestos to concentrate in the pleura. Together with the prolonged latency existing between exposure and the disease, this means that for many years we will continue to see pleural clinical manifestations from past exposure, in spite of the increasingly limited use of asbestos in recent decades. This exposure can show itself in different manifestations, both malign, such as mesothelioma, and benign, principally benign pleural effusion, pleural plaques, diffuse pleural fibrosis and massive atelectasis.

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Asbestos, asbestosis, pleural plaques and lung cancer

Cited by 122 publications

References 121 publications

Detection of pleural plaques in workers exposed to inhalation of natural fluoro-edenite fibres

Detection of pleural plaques in workers exposed to inhalation of natural fluoro-edenite fibres

Management options for the complicated pleural space

Enfermedades pleurales benignas inducidas por asbesto

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