Asbestos Bodies and Nonasbestos Ferruginous Bodies

Roggli, Victor L.

doi:10.1007/0-387-21819-x_3

Cited by 31 publications

(40 citation statements)

References 68 publications

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“…The particular propensity of amphibole asbestos to form asbestos bodies has already been emphasised by various authors [17,18], and this is in line with the relationship observed in this study between the presence of asbestos bodies in sputum and a history of exposure to crocidolite. SULOTTO et al [12], however, did not report such a relationship.…”

Section: Mineralogical Sputum Examination: Sensitivity and Specificitysupporting

confidence: 92%

Asbestos bodies in the sputum of asbestos workers: correlation with occupational exposure

Paris¹,

Galateau-Sallé²,

Creveuil³

et al. 2002

Eur Respir J

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A cross-sectional medical survey including collection of three consecutive sputum samples was carried out among 270 retired workers of a textile and friction materials factory, in order to investigate the relationship between asbestos body identification and asbestos exposure.The individual cumulative asbestos exposure, determined by means of a plant-specific job-exposure matrix based on asbestos air measurements in the workshops, proved to be heavy with a mean cumulative exposure of 217 fibres?mL -1 6yr. Macrophages and asbestos bodies were identified in sputum samples by light microscopy.The lung origin of the sputum, suggested by the presence of macrophages and/or asbestos bodies, was confirmed in 82.6% of subjects, and 53% of these samples were positive for asbestos bodies. The prevalence of asbestos bodies was not related to sex, smoking status or latency. Conversely, multivariate analysis showed a positive relationship with cumulative exposure, duration and intensity of exposure to asbestos, as well as age and time since retirement.These findings suggest that sputum analysis for asbestos bodies may remain a relevant and noninvasive marker of heavy occupational exposure to asbestos, even years after retirement. Owing to the new perspectives in lung cancer screening, it might contribute to the identification of high-risk subjects.

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Section: Mineralogical Sputum Examination: Sensitivity and Specificitysupporting

confidence: 92%

Asbestos bodies in the sputum of asbestos workers: correlation with occupational exposure

Paris¹,

Galateau-Sallé²,

Creveuil³

et al. 2002

Eur Respir J

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“…The upper limit of the control level was 2,540 uncoated fibers ( 5 pm or greater in length) per gram of wet lung. This value was based on SEM mineral fiber analyses for 19 control cases, as defined in earlier reports (i.e., macroscopically normal lungs at autopsy, no evidence of asbestos-related disease, and no documented history of asbestos exposure) [Roggli et al, 1986[Roggli et al, , 1992a.…”

Section: Materials and Methods Case Selectionmentioning

confidence: 99%

Asbestos‐related disease associated with exposure to asbestiform tremolite

Srebro

Roggli

1994

American J Industrial Med

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Tremolite is nearly ubiquitous and represents the most common amphibole fiber in the lungs of urbanites. Tremolite asbestos is not mined or used commercially but is a frequent contaminant of chrysotile asbestos, vermiculite, and talc. Therefore, individuals exposed to these materials or to end-products containing these materials may be exposed to tremolite. We have had the opportunity to do asbestos body counts and mineral fiber analysis on pulmonary tissue from five mesothelioma cases and two asbestosis cases with pulmonary tremolite burdens greater than background levels. There were no uncoated amosite or crocidolite fibers detected in any of these cases. Three patients were occupationally exposed to chrysotile asbestos; two patients had environmental exposures (one to vermiculite and one to chrysotile and talc) and one was a household contact of a shipyard worker. The tremolite burdens for the asbestosis cases were one to two orders of magnitude greater than those for the mesothelioma cases. Our study confirms the relationship between tremolite exposure and the development of asbestos-associated diseases. Furthermore, the finding of relatively modest elevations of tremolite content in some of our mesothelioma cases suggests that, at least for some susceptible individuals, moderate exposures to tremolite-contaminated dust can produce malignant pleural mesothelioma.

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“…Figure 4 shows a mica crystal that has reduced silver from solution to cause its precipitation at the redox-active edges. Similarly, in his descriptions of ferruginous bodies, Roggli (87) shows several particles of mica recovered from human lung (his Figures 3-18) (89).…”

Section: Oxidation-reductionmentioning

confidence: 86%

Mineral Properties and Their Contributions to Particle Toxicity

Guthrie¹

1997

Environmental Health Perspectives

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It has been recognized since at least as early as the mid-1500s that inhaled minerals (i.e., inorganic particles) can pose a risk. Extensive research has focused on the biological mechanisms responsible for asbestos-and silica-induced diseases, but much less attention has been paid to the mineralogical properties and geochemical mechanisms that might influence a mineral's biological activity. Several important mineralogical characteristics control a mineral's reactivity in geochemical reactions and are likely to determine its biological reactivity. In addition to the traditionally considered variables of particle size and shape, mineralogical characteristics such as dissolution behavior, ion exchange, sorptive properties, and the nature of the mineral surface (e.g., surface reactivity) play important roles in determining the toxicity and carcinogenicity of a particle. Ultimately, a mineral's species (which provides direct information on a mineral's structure and composition) is probably one of the most significant yet most neglected factors that must be considered in studies of toxicity and carcinogenicity.

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Asbestos Bodies and Nonasbestos Ferruginous Bodies

Cited by 31 publications

References 68 publications

Asbestos bodies in the sputum of asbestos workers: correlation with occupational exposure

Asbestos bodies in the sputum of asbestos workers: correlation with occupational exposure

Asbestos‐related disease associated with exposure to asbestiform tremolite

Mineral Properties and Their Contributions to Particle Toxicity

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