Asbestos exposure and laryngeal cancer mortality

Peng, Wenjia; Mi, Jing; Jiang, Yuhong

doi:10.1002/lary.25693

Cited by 33 publications

(23 citation statements)

References 38 publications

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“…In women, the two observed cases were in the mid and upper tertile of cumulative exposure and in the upper categories of TSFE. In summary, our cohort results provide little support to the association with laryngeal cancer, contrary to the two recent reviews by the Institute of Medicine [72] and by Peng et al [73]. Our study was limited by the use of mortality data and the absence of information on smoking and drinking.…”

Section: Discussioncontrasting

confidence: 95%

Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy

et al. 2019

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Background Despite the available information on cancer risk, asbestos is used in large areas in the world, mostly in the production of asbestos cement. Moreover, questions are raised regarding the shape of the dose response relation, the relation with time since exposure and the association with neoplasms in various organs. We conducted a study on the relationship between cumulative asbestos exposure and mortality from asbestos related diseases in a large Italian pool of 21 cohorts of asbestos-cement workers with protracted exposure to both chrysotile and amphibole asbestos. Methods The cohort included 13,076 workers, 81.9% men and 18.1% women, working in 21 Italian asbestos-cement factories, with over 40 years of observation. Exposure was estimated by plant and period, and weighted for the type of asbestos used. Data were analysed with consideration of cause of death, cumulative exposure and time since first exposure (TSFE), and by gender. SMRs were computed using reference rates by region, gender and calendar time. Poisson regression models including cubic splines were used to analyse the effect of cumulative exposure to asbestos and TSFE on mortality for asbestos-related diseases. 95% Confidence Intervals (CI) were computed according to the Poisson distribution. Results Mortality was significantly increased for ‘All Causes’ and ‘All Malignant Neoplasm (MN)’, in both genders. Considering asbestos related diseases (ARDs), statistically significant excesses were observed for MN of peritoneum (SMR: men 14.19; women 15.14), pleura (SMR: 22.35 and 48.10), lung (SMR: 1.67 and 1.67), ovary (in the highest exposure class SMR 2.45), and asbestosis (SMR: 507 and 1023). Mortality for ARDs, in particular pleural and peritoneal malignancies, lung cancer, ovarian cancer and asbestosis increased monotonically with cumulative exposure. Pleural MN mortality increased progressively in the first 40 years of TSFE, then reached a plateau, while peritoneal MN showed a continuous increase. The trend of lung cancer SMRs also showed a flattening after 40 years of TSFE. Attributable proportions for pleural, peritoneal, and lung MN were respectively 96, 93 and 40%. Conclusions Mortality for ARDs was associated with cumulative exposure to asbestos. Risk of death from pleural MN did not increase indefinitely with TSFE but eventually reached a plateau, consistently with reports from other recent studies. Electronic supplementary material The online version of this article (10.1186/s12940-019-0510-6) contains supplementary material, which is available to authorized users.

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Section: Discussioncontrasting

confidence: 95%

Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy

et al. 2019

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“…The International Agency for Research on Cancer (IARC) Working Group concluded that asbestos causes mesothelioma and cancer of the lung and larynx 3. Positive associations have been observed between exposure to all forms of asbestos and cancer of the pharynx,30 31 hypopharynx,32 larynx,33 34 oesophagus35 36 and stomach 37 38. In this study, we observed that nephrite processing increases the mortality risk from cancer in the same sites.…”

Section: Discussionsupporting

confidence: 62%

Cancer mortality in a population exposed to nephrite processing

Yang¹,

Huang

Shie

et al. 2016

Occup Environ Med

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“…During the course of research into the association between asbestos exposure and laryngeal cancer, I read the recent meta-analysis by Peng and colleagues. 1 It has come to my attention that the authors overlooked one of the largest cohort studies relevant to this topic, the study of Canadian asbestos miners published by Liddell and colleagues. 2 It is the purpose of this letter to update the calculations of Peng and colleagues by including the results from the Canadian mining cohort.…”

Section: Letter To the Editormentioning

confidence: 99%