Asbestos fiber concentration in the area surrounding a former asbestos cement plant and excess mesothelioma deaths in residents

Kumagai, Shinji; Kurumatani, Norio

doi:10.1002/ajim.20743

Cited by 25 publications

(18 citation statements)

References 23 publications

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“…Besides, older patients could be more likely to die due to more comorbidity. In contrast, and similarly to other studies in women exposed to asbestos from environmental [30] or household exposure [31, 32], our research shows that women have a higher risk of death during the first 40 years of exposure compared to men. However, this risk is not statistically significant.…”

Section: Discussionsupporting

confidence: 88%

“…We have not considered neither the intensity of exposure that could have varied across individuals [30] and time periods nor the recall bias of past exposures that could have caused biased estimates of association [37]. We have not quantified the effect of asbestos waste sites in an area free of naturally occurring asbestos [38, 39], which holds the highest Spanish mortality rate from mesothelioma [40].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Risk Factors of Mortality from All Asbestos-Related Diseases: A Competing Risk Analysis

Abós‐Herràndiz¹,

Rodríguez-Blanco

García-Allas³

et al. 2017

Canadian Respiratory Journal

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Background The mortality from all malignant and nonmalignant asbestos-related diseases remains unknown. The authors assessed the incidence and risk factors for all asbestos-related deaths. Methods The sample included 544 patients from an asbestos-exposed community in the area of Barcelona (Spain), between Jan 1, 1970, and Dec 31, 2006. Competing risk regression through a subdistribution hazard analysis was used to estimate risk factors for the outcomes. Results Asbestos-related deaths were observed in 167 (30.7%) patients and 57.5% of these deaths were caused by some type of mesothelioma. The incidence rate after diagnosis was 3,600 per 100,000 person-years. In 7.5% of patients death was non-asbestos-related, while pleural and peritoneal mesothelioma were identified in 87 (16.0%) and 18 (3.3%) patients, respectively. Conclusions Age, sex, household exposure, cumulative nonmalignant asbestos-related disease, and single malignant pathology were identified as risk factors for asbestos-related death. These findings suggest the need to develop a preventive approach to the community and to improve the clinical follow-up process of these patients.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Risk Factors of Mortality from All Asbestos-Related Diseases: A Competing Risk Analysis

Abós‐Herràndiz¹,

Rodríguez-Blanco

García-Allas³

et al. 2017

Canadian Respiratory Journal

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“…To the best of our knowledge, epidemiological studies undertaken to evaluate the risk of asbestos‐related diseases in Amagasaki City are few . Considering the typical long latency period of mesothelioma, former estimations need to be updated in order to reflect the latest public health consequences of exposure to asbestos.…”

Section: Introductionmentioning

confidence: 99%

Population‐based cohort study on health effects of asbestos exposure in Japan

et al. 2019

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Occupational asbestos exposure occurs in many workplaces and is a well‐known cause of mesothelioma and lung cancer. However, the association between nonoccupational asbestos exposure and those diseases is not clearly described. The aim of this study was to investigate cause‐specific mortality among the residents of Amagasaki, a city in Japan with many asbestos factories, and evaluate the potential excess mortality due to established and suspected asbestos‐related diseases. The study population consisted of 143 929 residents in Amagasaki City before 1975 until 2002, aged 40 years or older on January 1, 2002. Follow‐up was carried out from 2002 to 2015. Standardized mortality ratio (SMR) with its 95% confidence interval (CI) was calculated by sex, using the mortality rate of the Japanese population as reference. A total of 38 546 deaths (including 303 from mesothelioma and 2683 from lung cancer) were observed. The SMRs in the long‐term residents’ cohort were as follows: death due to all causes, 1.12 (95% CI, 1.10‐1.13) in men and 1.07 (95% CI, 1.06‐1.09) in women; lung cancer, 1.28 (95% CI, 1.23‐1.34) in men and 1.23 (95% CI, 1.14‐1.32) in women; and mesothelioma, 6.75 (95% CI, 5.83‐7.78) in men and 14.99 (95% CI, 12.34‐18.06) in women. These SMRs were significantly higher than expected. The increased SMR of mesothelioma suggests the impact of occupational asbestos exposure among men and nonoccupational asbestos exposure among women in the long‐term residents’ cohort. In addition, the high level of excess mortality from mesothelioma has persisted, despite the mixture of crocidolite and chrysotile no longer being used for three or four decades.

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“…But, few have researched the health effects of cement dust and asbestos [18,19], or heavy metals [20,21] derived from cement plants, thus a study on the relevance of dust and lung diseases of residents who live around these plants was rare. It is difficult to explain the relationship between environmental cement dust exposure and occurrence of a pulmonary disease due to the variety of other factors involved such as age, sex and smoking.…”

Section: Introductionmentioning

confidence: 99%

Ventilation impairment of residents around a cement plant

Kim¹,

Lee²,

Song³

et al. 2015

Ann of Occup and Environ Med

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ObjectivesTo identify adverse health effects due to air pollution derived from a cement plant in Korea. The ventilation impairment in residents around a cement plant was compared to another group through a pulmonary function test (PFT).MethodsFrom June to August of 2013, both a pre and post-bronchodilator PFT was conducted on a “more exposed group (MEG)” which consisted of 318 people who lived within a 1 km radius of a cement plant and a “less exposed group (LEG)” which consisted of 129 people who lived more than 5 km away from the same plant. The largest forced expiratory volume in a one second (FEV1) reading and a functional residual capacity (FVC) reading were recorded after examining the data from all of the usable curves that were agreed upon as valid by PFT experts of committee of National Institute of Environmental Research. The global initiative for chronic obstructive lung disease (GOLD) criteria for COPD, defined the FEV1/FVC ratio < 0.7 as the obstructive type, and the FEV1/FVC ratio ≧ 0.7 and FVC% predicted < 80% were as the restrictive type. The FVC% predicted value was estimated using Korean equation. We compared the proportion of lung function impairments between the MEG and the LEG by using a chi-square, and estimated the OR of obstructive and restrictive ventilation impairments by logistic regression.ResultsThe obstructive type impairment proportion was 9.7% in the MEG, whereas it was 8.5% in the LEG. The restrictive type was 21.6% in the MEG which was more than the 12.4% of the LEG. The odds ratio (OR) of total ventilation impairment in the MEG was 2.63 (95% CI 1.50 ~ 4.61) compared to the LEG. The OR of obstructive type in the MEG was 1.60 (95% CI 0.70 ~ 3.65), the smoking history was 3.10 (CI 1.10 ~ 8.66) whereas OR of restrictive type in the MEG was 2.55 (95% CI 1.37 ~ 4.76), the smoking history was 0.75 (95% CI 0.35 ~ 1.60) after adjusting for sex and age. Level of exposure to particulate played a role in both types. However, it appeared to be a significant variable in restrictive type, while smoking history was also an important variable in obstructive type.ConclusionAlthough this study is a limited cross-section study with a small number of subjects, ventilation impairment rate is higher in the MEG. There might be a possibility that it is due to long-term exposure to particulate dust generated by the cement plant.

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Asbestos fiber concentration in the area surrounding a former asbestos cement plant and excess mesothelioma deaths in residents

Abstract: This prediction suggests that considerable medical resources will be needed through 2049 as a result of past asbestos exposure in this region.

Cited by 25 publications

References 23 publications

Risk Factors of Mortality from All Asbestos-Related Diseases: A Competing Risk Analysis

Risk Factors of Mortality from All Asbestos-Related Diseases: A Competing Risk Analysis

Population‐based cohort study on health effects of asbestos exposure in Japan

Ventilation impairment of residents around a cement plant

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