2017
DOI: 10.1183/23120541.00022-2017
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Asbestos-related diseases in mineworkers: a clinicopathological study

Abstract: The accurate diagnosis of asbestos-related diseases is important because of past and current asbestos exposures. This study evaluated the reliability of clinical diagnoses of asbestos-related diseases in former mineworkers using autopsies as the reference standard.Sensitivity, specificity, positive predictive value and negative predictive value were calculated.The 149 cases identified had clinical examinations 0.3–7.4 years before death. More asbestos-related diseases were diagnosed at autopsy rather than clin… Show more

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Cited by 8 publications
(7 citation statements)
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“…However, if lung specimens are available from other investigations, then detection of silica, coal dust and/or asbestos fibres in lung tissue, combined with the typical pathological lesions, prove pneumoconiosis (Chong et al, 2006;Abraham, 2006). Although the mechanism of the diseases is still not completely elucidated, causality for silica, asbestos and coal dust is demonstrated by post mortem pathohistological evaluation of lung tissue for silicosis, asbestosis and coalworker pneumoconiosis (Ndlovu et al, 2017;Ndlovu et al, 2016;Nelson et al, 2010;Naidoo et al, 2005;Corbett et al, 1999;Hnizdo et al, 1993;Nelson et al, 2011;Murray et al, 1996). The presence of slate-grey to dense black silica dust-laden macrophages (sometimes visible silicate crystals), asbestos fibres and asbestos bodies and pigment-laden macrophages, and anthracitic pigmentation (coal dust) are evidence for exposure, but they are not sufficient for the diagnosis of pneumoconiosis (Landrigan, 2016).…”
Section: How the Risk Factor May Impact The Outcomementioning
confidence: 99%
“…However, if lung specimens are available from other investigations, then detection of silica, coal dust and/or asbestos fibres in lung tissue, combined with the typical pathological lesions, prove pneumoconiosis (Chong et al, 2006;Abraham, 2006). Although the mechanism of the diseases is still not completely elucidated, causality for silica, asbestos and coal dust is demonstrated by post mortem pathohistological evaluation of lung tissue for silicosis, asbestosis and coalworker pneumoconiosis (Ndlovu et al, 2017;Ndlovu et al, 2016;Nelson et al, 2010;Naidoo et al, 2005;Corbett et al, 1999;Hnizdo et al, 1993;Nelson et al, 2011;Murray et al, 1996). The presence of slate-grey to dense black silica dust-laden macrophages (sometimes visible silicate crystals), asbestos fibres and asbestos bodies and pigment-laden macrophages, and anthracitic pigmentation (coal dust) are evidence for exposure, but they are not sufficient for the diagnosis of pneumoconiosis (Landrigan, 2016).…”
Section: How the Risk Factor May Impact The Outcomementioning
confidence: 99%
“…The median latency period is 31 years, depending on the intensity of the exposure. The more intense the exposure, the more likely asbestosis will occur (7,8). Pleural plaques are the most common manifestation of asbestos exposure (9).…”
Section: Asbestos-related Diseases (Ard)mentioning
confidence: 99%
“…As doenças associadas ao amianto ou às fibras de asbestos são, em regra, resultantes da exposição profissional prolongada a este material, destacando-se a asbestose, as placas pleurais, o mesotelioma e o carcinoma do pulmão. 1 As fibras de asbestos presentes em diversos tipos de materiais, com numerosas aplicações na indústria da construção, foram particularmente utilizadas no século XX. Em Portugal, a sua utilização é proibida desde 2005 (Decreto--Lei nº 101/2005, de 23 de junho).…”
Section: Introductionunclassified
“…As fibras de amianto são inaladas e acumulam-se no espaço pleural, causando irritação e um processo inflamatório crónico, penetram nas células mesoteliais induzindo mutações genéticas e a expressão de proto-oncogenes, resultando numa proliferação celular anormal e crescimento tumoral. 1,3 O período de latência médio, entre a exposição a amianto e o início da sintomatologia é de trinta a quarenta anos. 1,3 Manifesta-se geralmente, por sintomas inespecíficos como dispneia, toracalgia e/ou perda ponderal.…”
Section: Introductionunclassified
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