Asbestos

Hammar, Samuel P.; Dodson, Ronald F.

doi:10.1007/978-1-4757-3935-0_28

Cited by 23 publications

(9 citation statements)

References 226 publications

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“…In this case such a conclusion is even more logical, since the frequently compounding issue of a history of smoking is absent, as this individual was a lifetime nonsmoker. The tissue burden for asbestos bodies and uncoated asbestos fibers in the exhumed lung was at levels consistent with past occupational exposures (Hammar & Dodson, 1994). The residual numbers of asbestos fibers and asbestos bodies in the tissue were very high, considering that the lung is highly efficient at removing inhaled dust.…”

Section: Discussionsupporting

confidence: 64%

“…Further compounding the usefulness of relying solely on the presence of asbestos bodies, as an indicator of past exposure to asbestos, is the fact that the most widely used commercial type of asbestos, chrysotile, is most often inhaled as a short fiber. Because of this, chrysotile is rarely found as the core material of asbestos bodies (Hammar & Dodson, 1994) even if there are large numbers of uncoated asbestos fibers of this type in the tissue.…”

mentioning

confidence: 94%

“…Another important variable is the inherent efficiency of the individual's tissue to coat inhaled particulates. For example, certain animal species and some individual humans are inefficient generators of asbestos bodies (if their tissue forms coatings at all) even when appropriate populations of longer fibers are in their lung tissue (Davis, 1970;Hammar & Dodson, 1994). As a result, lung samples from occupationally exposed humans show significant variations in the ratio of uncoated asbestos fibers to 789 790 R. F. DODSON ET AL.…”

mentioning

confidence: 95%

“…Considerable data exist with regard to both the absolute and relative numbers of asbestos bodies found in tissue from environmental and occupationally exposed groups (Hammar & Dodson, 1994). Work from animal models in our laboratory indicates that the formation of asbestos bodies in lung tissue occurs over a period of months following exposure and requires the presence of a population of fibers longer than 8 µm to stimulate formation.…”

mentioning

confidence: 96%

“…Governa and Rosanda (1972) suggested that mucopolysaccharides might act as a matrix for subsequent iron deposition on the coating. For asbestos body formation to occur, fibers must not only be of the appropriate length, but also appear to require a certain diameter and surface features (Dodson et al, 1983;Hammar & Dodson, 1994). Another important variable is the inherent efficiency of the individual's tissue to coat inhaled particulates.…”

mentioning

confidence: 98%

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Stability of Ferruginous Bodies in Human Lung Tissue Following Death, Embalmment, and Burial

Dodson

Atkinson

O’Sullivan

2005

Inhalation Toxicology

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The identification of asbestos bodies in tissue sections is an indicator of past exposure to longer asbestos fibers. These structures are formed in lung tissue as a consequence of interactions with pulmonary macrophages resulting in the deposition of a ferroprotein (ferruginous) coating on the fiber. While the process of ferruginous body formation is known to take months in animal tissue, there is no published information on the stability of ferruginous bodies in tissue following death. The material assessed in the present study was obtained from lung material collected from an exhumed body approximately 8(1/2) mo after death, embalmment, and burial. Tissue sections were reviewed for the presence of asbestos bodies. Additional pieces of lung tissue were digested, with the digestate being evaluated by light microscopy for ferruginous bodies and by electron microscopy for uncoated asbestos fibers and core analysis of asbestos bodies. Classical ferruginous (asbestos) bodies were found in abundance in the tissue sections including in areas with fibrosis. The levels of uncoated asbestos fibers and classical appearing ferruginous bodies (asbestos bodies) were consistent with occupational levels of tissue burden. The data from this study indicate that ferruginous bodies remain morphologically stable within the tissue for months following death, embalmment, and burial. Thus the lung tissue from this exhumed individual was usable not only to pathologically confirm asbestosis but also to provide quantitative data of occupational exposure to asbestos.

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Section: Discussionsupporting

confidence: 64%

mentioning

confidence: 94%

mentioning

confidence: 95%

mentioning

confidence: 96%

mentioning

confidence: 98%

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Stability of Ferruginous Bodies in Human Lung Tissue Following Death, Embalmment, and Burial

Dodson

Atkinson

O’Sullivan

2005

Inhalation Toxicology

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Tissue burden of asbestos in nonoccupationally exposed individuals from east Texas

et al. 1999

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Background The potential for asbestos exposure among members of the general population is appreciable, considering its widespread use in many products. This study examined tissue burden of asbestos in such a population. Methods A group of 33 individuals who had no work history of occupational exposure to asbestos were included in the study. Tissue sections from areas adjacent to those sites sampled for digestion were found to be without ferruginous bodies (FB) or histopathology consistent with asbestos‐induced changes. All individuals had 20 or less FBs per gram of digested wet lung, a number considered to reflect general population levels. Tissue analysis of uncoated fiber burden was carried out by analytical electron microscopy. There was a trend of a higher likelihood of FB and asbestos fiber content correlated with age. Results The data are not consistent with the findings that chrysotile is readily found in lung tissue from the general population, in that none was found in 19 of the cases. It was almost as likely that one would find anthophyllite (12 of 33 cases) in this study. The commercial amphiboles (amosite and crocidolite) were occasionally found in the tissue from the general population and, when observed, were few in numbers. Twenty‐six of the patients had no FBs and ten had no uncoated asbestos fibers within the limits of detectability in this study. Conclusions The total tissue burden of asbestos in this study is much less than earlier reported observations from other general populations. Am. J. Ind. Med. 35:281–286, 1999. © 1999 Wiley‐Liss, Inc.

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