Ascending projections of the cerebellar fastigial nucleus to the hippocampus, amygdala, and other temporal lobe sites: Evoked potential and histological studies in monkeys and cats

Heath, Robert G.; Harper, Jon W.

doi:10.1016/0014-4886(74)90118-6

Cited by 219 publications

(139 citation statements)

References 22 publications

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“…Although several studies have demonstrated the direct anatomic connection from fastigial nucleus to encephalic regions as amygdala, hippocampus and cerebral cortex, 21 as well as the projection through thalamus of interpositus and dentate nucleus to cerebral cortex, 22 this is the first time that deep cerebellar nuclei neurons are shown to be affected at early stages of AD progression.…”

Section: Resultsmentioning

confidence: 96%

Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment

Esquerda-Canals¹,

Marti²,

Rivera-Hernández³

et al. 2013

mAbs

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Section: Resultsmentioning

confidence: 96%

Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment

Esquerda-Canals¹,

Marti²,

Rivera-Hernández³

et al. 2013

mAbs

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“…Snider showed that vermian and fastigial stimulation in the cat induces electrophysiological responses in the basolateral amygdala, a crucial site for fear behavior, and in septum and hippocampus (Snider and Maiti, 1976). These results have been confirmed in rats (Heath et al, 1978) and monkeys (Heath and Harper, 1974). In addition, the vermis by way of fastigial nucleus projects (i) to periaqueductal gray area, a region that has anatomical bidirectional connections with amygdala and septum and (ii) to the locus coeruleus and the ventral tegmental area, the centers of catecholaminergic systems (Berntson and Torello, 1982).…”

Section: Neural Basis Of the Cerebellar Involvement In Learned Fearmentioning

confidence: 86%

Cerebellum and emotional behavior

Sacchetti¹,

Scelfo²,

Strata³

2009

Neuroscience

129

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Fear conditioning involves learning that a previously neutral stimulus (CS) predicts an aversive unconditioned stimulus (US). Lesions of the cerebellar vermis may affect fear memory without altering baseline motor/autonomic responses to the frightening stimuli. Reversible inactivation of the vermis during the consolidation period impairs retention of fear memory. In patients with medial cerebellar lesions conditioned bradycardia is impaired. In humans, cerebellar areas around the vermis are activated during mental recall of emotional personal episodes, if a loved partner receives a pain stimulus, and during learning of a CS-US association. Moreover, patients with cerebellar stroke may fail to show overt emotional changes. In such patients, however, the activity of several areas, including ventromedial prefrontal cortex, anterior cingulate, pulvinar and insular cortex, is significantly increased relative to healthy subjects when exposed to frightening stimuli. Therefore, other structures may serve to maintain fear response after cerebellar damage. These data indicate that the vermis is involved in the formation of fear memory traces. We suggest that the vermis is not only involved in regulating the autonomic/motor responses, but that it also participates in forming new CS-US associations thus eliciting appropriate responses to new stimuli or situations. In other words, the cerebellum may translate an emotional state elaborated elsewhere into autonomic and motor responses.

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“…Error bars represent standard error. (Damasio, et al, 2000;Sacchetti, et al, 2002), through direct and indirect anatomical connections with the hippocampus, amygdala, and PAG (Heath and Harper, 1974;Snider and Maiti, 1976). An intimate functional relationship between the vermis and hippocampus has been documented (Newman and Reza, 1979), including in fear-related memories (Maren and Holt, 2004).…”

Section: Discussionmentioning

confidence: 99%

Aversive stimuli exacerbate defensive motor behaviour in motor conversion disorder

et al. 2016

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A B S T R A C TConversion disorder or functional neurological symptom disorder (FND) can affect the voluntary motor system, without an organic cause. Functional symptoms are thought to be generated unconsciously, arising from underlying psychological stressors. However, attempts to demonstrate a direct relationship between the limbic system and disrupted motor function in FND are lacking. We tested whether negative affect would exacerbate alterations of motor control and corresponding brain activations in individuals with FND. Ten patients and ten healthy controls produced an isometric precision-grip contraction at 10% of maximum force while either viewing visual feedback of their force output, or unpleasant or pleasant emotional images (without feedback). Force magnitude was continuously recorded together with change in brain activity using fMRI. For controls, force output decayed from the target level while viewing pleasant and unpleasant images. Patients however, maintained force at the target level without decay while viewing unpleasant images, indicating a pronounced effect of negative affect on force output in FND. This emotional modulation of force control was associated with different brain activation patterns between groups. Contrasting the unpleasant with the pleasant condition, controls showed increased activity in the inferior frontal cortex and pre-supplementary motor area, whereas patients had greater activity in the cerebellum (vermis), posterior cingulate cortex, and hippocampus. Engagement of a cerebellar-limbic network in patients is consistent with heightened processing of emotional salience, and supports the role of the cerebellum in freezing responses in the presence of aversive events. These data highlight a possible neural circuit through which psychological stressors elicit defensive behaviour and modulate motor function in FND.

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Ascending projections of the cerebellar fastigial nucleus to the hippocampus, amygdala, and other temporal lobe sites: Evoked potential and histological studies in monkeys and cats

Cited by 219 publications

References 22 publications

Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment

Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment

Cerebellum and emotional behavior

Aversive stimuli exacerbate defensive motor behaviour in motor conversion disorder

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