Asciminib Maintains Antibody-Dependent Cellular Cytotoxicity against Leukemic Blasts
Samuel J. Holzmayer,
Joseph Kauer,
Jonas Mauermann
et al.
Abstract:B cell acute lymphoblastic leukemia (B-ALL) is characterized by an accumulation of malignant precursor cells. Treatment consists of multiagent chemotherapy followed by allogeneic stem cell transplantation in high-risk patients. In addition, patients bearing the BCR-ABL1 fusion gene receive concomitant tyrosine kinase inhibitor (TKI) therapy. On the other hand, monoclonal antibody therapy is increasingly used in both clinical trials and real-world settings. The introduction of rituximab has improved the outcome… Show more
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