2022
DOI: 10.3390/nu14214665
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Ascophyllum nodosum and Fucus vesiculosus Extracts Improved Lipid Metabolism and Inflammation in High-Energy Diet–Induced Hyperlipidemia Rats

Abstract: Ascophyllum nodosum and Fucus vesiculosus both contain unique polyphenols called phlorotannins. Phlorotannins reportedly possess various pharmacological activities. A previous study reported that the activity of phlorotannin is strongly correlated with the normalization of metabolic function, and phlorotannins are extremely promising nutrients for use in the treatment of metabolic syndrome. To date, no study has explored the antihyperlipidemic effects of phlorotannins from A. nodosum and F. vesiculosus in anim… Show more

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Cited by 5 publications
(7 citation statements)
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“…Considering that the F. vesiculosus extract studied is rich in phlorotannins and peptides [10], and given that NPC1 proteins were only identified in cells exposed to the extract, we can propose that the compounds in the extract induce the expression of this protein. This effect is in line with different studies with F. vesiculosus seaweeds and extracts from other phlorotannin-rich seaweeds describing their hypocholesterolemic effects and their potential in the prevention of cardiovascular diseases [9,12,43,44].…”
Section: Proteomic Analysissupporting
confidence: 89%
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“…Considering that the F. vesiculosus extract studied is rich in phlorotannins and peptides [10], and given that NPC1 proteins were only identified in cells exposed to the extract, we can propose that the compounds in the extract induce the expression of this protein. This effect is in line with different studies with F. vesiculosus seaweeds and extracts from other phlorotannin-rich seaweeds describing their hypocholesterolemic effects and their potential in the prevention of cardiovascular diseases [9,12,43,44].…”
Section: Proteomic Analysissupporting
confidence: 89%
“…Brown seaweeds are one of the world's most consumed seaweeds and one of the most studied seaweeds in this field [6]. Several studies with different compounds, such as phlorotannins, carotenoids, and polysaccharides extracted from brown algae species, have already reported their hypocholesterolemic effect [7][8][9]. Phlorotannins, a class of bioactive polyphenolic compounds produced by brown algae, have been characterised for their potential to prevent atherosclerosis, with several studies reporting their ability to reduce blood lipid levels and total cholesterol, particularly through their ability to decrease cholesterol synthesis and intestinal absorption [9][10][11][12].…”
Section: Introductionmentioning
confidence: 99%
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“…The quantity of fat absorbed from the gastrointestinal tract (GIT) and re-esterified lipids (in various lipoproteins) into low-density lipoproteins (LDL) by the liver determines the cholesterol serum levels in calves [40]. A. nodosum increased lipid metabolism in rats, thereby promoting antioxidant activity [41]. One of the principal mineral elements in A. nodosum is iodine, which is related to higher levels of total cholesterol.…”
Section: Metabolic Profile Antioxidant Barrier and Immunoenzymatic An...mentioning
confidence: 99%
“…Brown seaweeds are one of the world most consumed seaweeds and one of the furthermost studied seaweeds in this area [6]. Several studies with different compounds, such as phlorotannins, carotenoids and polysaccharides extracted from brown algae species already reported its 2 hypocholesterolemic effect [7][8][9]. Phlorotannins, a class of bioactive polyphenolic compounds produced by brown algae, have been characterised for their potential to prevent atherosclerosis, with several studies reporting their ability to decrease blood lipid levels and total cholesterol, particularly due to their capacity to reduce cholesterol synthesis and intestinal absorption [9][10][11][12].…”
Section: Introductionmentioning
confidence: 99%