Ascorbic Acid Aggravates Secondary Hyperoxalemia in Patients on Chronic Hemodialysis

Balcke, P; Schmidt, Paul; Zazgórnik, J; Kopsa, H; Haubenstock, Alexander

doi:10.7326/0003-4819-101-3-344

Cited by 62 publications

(15 citation statements)

References 8 publications

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“…Hyperoxalemia in patients receiving dialysis was induced by vitamin C when it was administered intravenously in repeated 1-g doses, 57 but there is no rationale for such use. Vitamin C daily doses of 500 mg or more could possibly produce hyperoxalemia in patients receiving dialysis.…”

Section: Adverse Effectsmentioning

confidence: 99%

Criteria and Recommendations for Vitamin C Intake

Levine¹

1999

JAMA

483

335

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Section: Adverse Effectsmentioning

confidence: 99%

Criteria and Recommendations for Vitamin C Intake

Levine¹

1999

JAMA

483

335

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“…The patients are sometimes treated with very high oral or parenteral doses of vitamin C. How ever, this is clearly contraindicated, as has been documented in several reports showing that oxalosis due to renal failure may be severely aggravated by vitamin C. Complica tions due to oxalate deposits in several organs and other pathological conditions have been described after excessively high doses of vita min C (in 1 case 60 g i.v. ), including cuta neous oxalosis with calcifications of fingers, accelerated renal failure, and death [54][55][56][57][58][59][60].…”

Section: Patients With Renal Failure and Vitamin Cmentioning

confidence: 99%

No Contribution of Ascorbic Acid to Renal Calcium Oxalate Stones

Gerster¹

1997

Ann Nutr Metab

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Even though a certain part of oxalate in the urine derives from metabolized ascorbic acid (AA), the intake of high doses of vitamin C does not increase the risk of calcium oxalate kidney stones due to physiological regulatory factor: gastrointestinal absorption as well as renal tubular reabsorption of AA are saturable processes, and the metabolic transformation of AA to oxalate is limited as well. Older assays for urinary oxalate favored in vitro conversion of AA to oxalate during storage and processing of the samples. Recurrent stone formers and patients with renal failure who have a defect in AA or oxalate metabolism should restrict daily vitamin C intakes to -100 mg. But in the large-scale Harvard Prospective Health Professional Follow-Up Study, those groups in the highest quintile of vitamin C intake (> 1,500 mg/day) had a lower risk of kidney stones than the groups in the lowest quintiles.

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“…A genetic condition which results in decreased levels of the enzyme glucose-6-phosphate dehydrogenase may cause sufferers to develop hemolytic anemia after up taking specific oxidizing substances, like very large dosages of vitamin C. There are few reports of adverse effects other than mild osmotic diarrhea was also associated with vitamin C supplementation, and collectively the other hypothesized side effects are of undetermined relevance [103][104][105][106].…”

Section: Vitamin Cmentioning

confidence: 99%

Adverse Effects and Side Effects on Vitamin Therapy: A Review

Korah

Pv²,

Rajeswari³

et al. 2017

Asian J Pharm Clin Res

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Vitamins are essential for our daily life. Its shortage in our body can cause many disorders, decreased enzyme activities also affect the genetic factors. Vitamins should be supplied through the diet in the required amount. If it is not supplied properly, vitamin tablets will be prescribed. And also vitamin tablets are the co-medication for therapies such as anticancer, antitubercular, antiviral and anti-HIV treatments. Many newspapers reported that vitamin therapies are causing major health problems like nephro/urolithiasis, it can increase mortality rates in smokers by increasing the risk of lung cancer, it can cause abortion when it is taken during pregnancy. Thus here, we reviewed the adverse effects of vitamin therapy from various reported cases, books, instructions provided from various health organizations and also newspapers, and magazines. It can help health professionals to control and monitor the vitamin therapies and make awareness about the adverse effects and possible side effects of regular vitamin uptake to society.

show abstract

Ascorbic Acid Aggravates Secondary Hyperoxalemia in Patients on Chronic Hemodialysis

Cited by 62 publications

References 8 publications

Criteria and Recommendations for Vitamin C Intake

Criteria and Recommendations for Vitamin C Intake

No Contribution of Ascorbic Acid to Renal Calcium Oxalate Stones

Adverse Effects and Side Effects on Vitamin Therapy: A Review

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