Ascorbic acid and EDTA treatment of lead toxicity in rats

Ra, Goyer; Mg, Cherian

doi:10.1016/0024-3205(79)90215-7

Cited by 78 publications

(46 citation statements)

References 7 publications

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“…It has also been clinically proven with mice that EDTA-Pb-AsC (Goyer & Cherian, 1978) and EDTA-Pb-Vit B 1 (Kim, 1992) ternary systems were more effective than EDTA-Pb binary system to reduce and control the organ distribution of lead effectively. Therefore, the findings of this work have quantitatively proved the clinical investigations reported.…”

Section: Resultsmentioning

confidence: 99%

“…The only way of curing lead toxicity is chelation therapy, which comes in two modes; single ligand and mixed ligand chelation therapy. This involves the formation of chelate complexes of toxic metal ions with administered drugs which can be easily excreted via urine or feces (Chisolm,1968;Goyer & Cherian, 1978;May and Williams, 1979;Bulman et al, 1979;Das, 1990;Wang et.al.,2006). On the other hand, single and mixed ligand chelates of metals with various ligand molecules have been studied extensively related to various aspects quantitatively (Nakayama et.al., 1989;Florence 1982;Mildvan et al,1967;Shelke & Jahagirdar,1976;Maktell and Carey,1967;Moustafa, 2005) and many of the mixed chelate systems of bio-molecules with biologically important metals like Cu, Ni and Zn investigated were used as models of biochemistry to understand more complicated biological reactions (Mildvan & Cohn, 1966;El-Haty et al,1995;Brumas et al,1995;Kleszczewska, 1999;Bucci, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Study on mixed ligand complexes of Pb(II) with EDTA and dietary ligands to investigate the applicability on chelation therapy

Chandrathilaka

Hettiarachchi

2017

Ceylon J. Sci.

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Lead is the most distributed toxic metal in the world and chelation therapy is a remedy for removing it from the body, if a person is intoxicated. Stability constants of both binary and mixed ligand complexes of Pb(II) with salicylic acid, ascorbic acid, vitamin B 1 (thiamine), vitamin B 3 (niacin) and Na 2 EDTA were potentiometrically studied, in aqueous media at the temperature of 37.0 ± 0.2 ⁰ C and the ionic strength of 0.15 mol dm -3 in order to identify better mixed ligand systems suitable for chelation therapy of lead. Both metal-ligand and proton-ligand formation constants were calculated using IrvingRossotti equations. The Formation of ternary complexes was further confirmed theoretically by plotting composite curves. Δ log K values calculated revealed that all mixed complexes were more stable than the complexes of corresponding binary systems. EDTA-Vitamin B 1 and EDTA-Ascorbic mixed complexes with Pb(II) disclosed very high stability constants, which were two times greater than that of EDTA binary complex. Vitamin B 1 revealed a remarkably high ability in forming mixed ligand complexes with all other four ligands. Results of this work clearly indicate that (EDTA-Vitamin B 1 ), (EDTA-Ascorbic), (Vitamin B 1 -Ascorbic), (Vitamin B 1 -Salicylic) and (Vitamin B 1 -Vitamin B 3 ) combinations can be used for detoxification of lead more effectively using dietary ligands.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Study on mixed ligand complexes of Pb(II) with EDTA and dietary ligands to investigate the applicability on chelation therapy

Chandrathilaka

Hettiarachchi

2017

Ceylon J. Sci.

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“…Their intake prevented the growth depression and anaemia caused and reduced tissue lead contents, specifically in bone in which most of the accumulated lead was observed to be present. 37 Goyer and Cherian 38 claimed that chelating effect of VC was equivalent to that of EDTA when examined in relation to lead toxicity.…”

Section: -34mentioning

confidence: 99%

The Medicinal Value and the Numerous Sources of Vitamin C - A Review

Jain¹

2015

JNHFE

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“…It acts mainly as an antioxidant molecule and its beneficial effects could be attributed to its ability to complex with lead "Flora and Tandon (11) ". Early reports found that vitamin C might act as a possible chelator of lead, with similar potency to that of EDTA "Goyer and Cherion (12) ". Vitamin C could protect somatic cells of reproductive system against toxins that act through oxygen radical mechanism "Anderson et al (13) ".…”

Section: Introductionmentioning

confidence: 99%