2013
DOI: 10.1371/journal.pone.0066691
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Ascorbic Acid Biosynthesis and Brackish Water Acclimation in the Euryhaline Freshwater White-Rimmed Stingray, Himantura signifer

Abstract: L-gulono-γ-lactone oxidase (Gulo) catalyzes the last step of ascorbic acid biosynthesis, which occurs in the kidney of elasmobranchs. This study aimed to clone and sequence gulonolactone oxidase (gulo) from the kidney of the euryhaline freshwater stingray, Himantura signifer, and to determine the effects of acclimation from freshwater to brackish water (salinity 20) on its renal gulo mRNA expression and Gulo activity. We also examined the effects of brackish water acclimation on concentrations of ascorbate, de… Show more

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Cited by 12 publications
(7 citation statements)
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“…In Drosophila , ascorbate was detected in flies raised on an apparent ascorbate-free diet, but no evidence for endogenous biosynthesis of the molecule was shown ( 39 ). Because no studies have recently explored the presence or possible biosynthesis of ascorbate in invertebrates, several authors have concluded that invertebrates are incapable of synthesizing this molecule ( 33 , 40 , 41 ). Based on the important roles of ascorbate in metabolism and in resistance to reactive oxygen species, we felt that it was important to establish in an invertebrate species both the levels of ascorbate and how it may be biosynthesized.…”
Section: Introductionmentioning
confidence: 99%
“…In Drosophila , ascorbate was detected in flies raised on an apparent ascorbate-free diet, but no evidence for endogenous biosynthesis of the molecule was shown ( 39 ). Because no studies have recently explored the presence or possible biosynthesis of ascorbate in invertebrates, several authors have concluded that invertebrates are incapable of synthesizing this molecule ( 33 , 40 , 41 ). Based on the important roles of ascorbate in metabolism and in resistance to reactive oxygen species, we felt that it was important to establish in an invertebrate species both the levels of ascorbate and how it may be biosynthesized.…”
Section: Introductionmentioning
confidence: 99%
“…It is a sugar acid, having antioxidant properties and can prevent or treat common cold and scurvy. It also acts as a cofactor and thus maintain activity of various enzymes [ 26 27 , 32 , 40 41 ]. The degradation of AA is very important and is considered to be the major cause of color and quality change during storage or processing of food materials [ 40 , 42 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, it can travel freely along the river and may re-enter brackish/estuarine environments for reproduction (Otake et al, 2005 ). Recently, Wong et al ( 2013 ) demonstrated that H. signifer might experience greater salinity-induced oxidative stress in fresh water than in brackish water, possibly related to its short history of fresh water invasion. In the laboratory, H. signifer can survive in fresh water (salinity 0.7) indefinitely or in brackish water (salinity 20) for at least two weeks (Tam et al, 2003 ; Ip et al, 2009 ).…”
Section: Introductionmentioning
confidence: 99%