Ascorbic acid blocks hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes

Hoffman, Robert P.; Dye, Amanda S.; Bauer, John

doi:10.1111/j.1399-5448.2012.00882.x

Cited by 9 publications

(5 citation statements)

References 20 publications

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“…In endothelial cells, l -ascorbic acid blocks the oxidative stress-induced increase in endothelial permeability by maintaining NO ∙ levels ( 109 ) . In adults with T1D, the combination of euglycaemia and ascorbic acid therapy has been observed to normalise endothelial function ( 110 ) in addition to the reduction in acute hyperglycaemia-induced impairment of endothelial function ( 111 ) . l -Ascorbic acid reversed the endothelial dysfunction in patients with coronary artery disease.…”

Section: Alternative Treatment Strategiesmentioning

confidence: 99%

Reversibility of endothelial dysfunction in diabetes: role of polyphenols

et al. 2016

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The endothelium, a thin single sheet of endothelial cells, is a metabolically active layer that coats the inner surface of blood vessels and acts as an interface between the circulating blood and the vessel wall. The endothelium through the secretion of vasodilators and vasoconstrictors serves as a critical mediator of vascular homeostasis. During the development of the vascular system, it regulates cellular adhesion and vessel wall inflammation in addition to maintaining vasculogenesis and angiogenesis. A shift in the functions of the endothelium towards vasoconstriction, proinflammatory and prothrombic states characterise improper functioning of these cells, leading to endothelial dysfunction (ED), implicated in the pathogenesis of many diseases including diabetes. Major mechanisms of ED include the down-regulation of endothelial nitric oxide synthase levels, differential expression of vascular endothelial growth factor, endoplasmic reticulum stress, inflammatory pathways and oxidative stress. ED tends to be the initial event in macrovascular complications such as coronary artery disease, peripheral arterial disease, stroke and microvascular complications such as nephropathy, neuropathy and retinopathy. Numerous strategies have been developed to protect endothelial cells against various stimuli, of which the role of polyphenolic compounds in modulating the differentially regulated pathways and thus maintaining vascular homeostasis has been proven to be beneficial. This review addresses the factors stimulating ED in diabetes and the molecular mechanisms of natural polyphenol antioxidants in maintaining vascular homeostasis.

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Section: Alternative Treatment Strategiesmentioning

confidence: 99%

Reversibility of endothelial dysfunction in diabetes: role of polyphenols

et al. 2016

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“…Diabetes is associated with various micro vascular and macro vascular complications. Hyperglycaemia in diabetes is responsible for micro vascular ROS generation which causes endothelial dysfunction [167] and vitamin C blocks acute hyperglycaemic impairment of endothelial function in diabetic subjects [168]. One of the most important micro vascular complications is diabetic nephropathy.…”

Section: Vitamin C and Diabetesmentioning

confidence: 99%

Vitamin C in Disease Prevention and Cure: An Overview

et al. 2013

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The recognition of vitamin C is associated with a history of an unrelenting search for the cause of the ancient haemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential for the development and maintenance of connective tissues. It plays an important role in bone formation, wound healing and the maintenance of healthy gums. Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. It is an antioxidant that protects body from free radical damage. It is used as therapeutic agent in many diseases and disorders. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight off infections. However the significance and beneficial effect of vitamin C in respect to human disease such as cancer, atherosclerosis, diabetes, neurodegenerative disease and metal toxicity however remains equivocal. Thus further continuous uninterrupted efforts may open new vistas to understand its significance in disease management.

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“…In patients with poorly controlled type 1 diabetes ascorbic acid infusion, alone, only partially restores endothelial function. Acute ascorbic acid infusion blocks the acute effects of hyperglycemia in adolescents with type 1 diabetes [ 32 ]. Therapeutically, vitamin C decreases transcapillary albumin escape [ 26 ] and urinary albumin excretion [ 33 ] in adults with T1DM.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes Mellitus

Cazeau

Huang

Bauer

et al. 2016

Journal of Diabetes Research

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Background/Objectives. Endothelial dysfunction due to hyperglycemia-induced oxidative damage is an important predictor of future cardiovascular risk in patients with type 1 diabetes mellitus (T1DM) and is present in adolescent T1DM. We hypothesized that combined treatment with the antioxidant vitamins C and E might improve endothelial function (EF) and other biochemical risk factors in adolescents with T1DM. Subjects/Methods. Open-label antioxidant supplementation was given for six weeks with endpoint measurements collected at baseline and study completion. Endpoints measured included EF and plasma measurements of biochemical endothelial risk. Results. Two males and 7 females were studied. Mean age was 12.9 ± 0.9 yrs; mean T1DM duration was 5.5 ± 2.5 yrs; mean BMI was 22.1 ± 3.8 kg/m2; and mean hemoglobin A1c was 9.3 ± 1.1%. No differences were found for EF, high sensitivity CRP, total antioxidant capacity, adiponectin, or endothelial progenitor cells (EPCs) between before and after combined vitamin C and E therapy. Conclusions. Our negative study results do not support previous findings of decreased oxidative damage, improved endothelial function, and increased vascular repair capacity with antioxidant therapy. Longer term studies may be needed to determine the effects, if any, of combined antioxidant therapy on EPCs, EF, and markers of micro- and macrovascular complications in T1DM.

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Ascorbic acid blocks hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes

Cited by 9 publications

References 20 publications

Reversibility of endothelial dysfunction in diabetes: role of polyphenols

Reversibility of endothelial dysfunction in diabetes: role of polyphenols

Vitamin C in Disease Prevention and Cure: An Overview

Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes Mellitus

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