Ascorbic Acid Decreases the Binding Affinity of the AT1 Receptor for Angiotensin II

Leclerc, Patrice C.; Proulx, Christophe D.; Arguin, Guillaume; Bélanger, Simon; Gobeil, Fernand; Escher, Emanuel; Leduc, Richard; Guillemette, Gaétan

doi:10.1038/ajh.2007.1

Cited by 32 publications

(27 citation statements)

References 28 publications

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“…The researchers focused on the hypotensive action of ascorbic acid based on its biological function to explain their observed results (37)(38)(39). In addition, one recent study showed that ascorbic acid interfered with angiotensin activity and explained the blood pressure lowering effect of ascorbic acid (40). However, our result might be speculated to be due to the difference in blood pressure between the DM and control groups because high blood pressure could increase renal flow and decrease the body pool size of nutrients.…”

Section: Discussionmentioning

confidence: 99%

Vitamin C Nutriture in Newly Diagnosed Diabetes

Shim

Paik

Shin

et al. 2010

J Nutr Sci Vitaminol

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SummaryThis study was performed to investigate the relationship between serum Lascorbic acid, vitamin C intake, and diabetes in a nested case-control study. A cross-sectional survey of diet and health was conducted in 2,048 adults with an age of 30 y or older in Yonchon County, Korea. An oral glucose tolerance test was administered to all participants. One hundred cases of newly diagnosed diabetes were identified. Two healthy controls for each case matched with age, gender, drinking status, and smoking status were selected among the survey participants. L -Ascorbic acid levels were analyzed in fasting serum samples and one 24-h dietary recall was performed. Dietary vitamin C intake of persons with diabetes was 50.1 Ϯ 47.6 mg/d and that of controls was 55.1 Ϯ 41.1 mg/d. People with diabetes (22.3 Ϯ 16.8 mol/L) have lower serum ascorbic acid levels than their controls (26.3 Ϯ 17.0 mol/L) and the difference was significant by paired t -test ( p Ͻ 0.01). The association between diabetes and serum ascorbic acid level was still significant in non-smokers (24.2 Ϯ 17.8 mol/L for the diabetes group and 29.5 Ϯ 16.7 mol/L for the control group, p Ͻ 0.01) but not in smokers (19.4 Ϯ 15.7 mol/L for the diabetes group and 21.2 Ϯ 16.0 mol/L for the control group). Our results suggest that diabetes and smoking interactively affect serum ascorbic acid levels. Since this population had poor nutritional status of vitamin C, further investigation of association between serum ascorbic acid level and diabetes and smoking by the level of vitamin C consumption is warranted.

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Section: Discussionmentioning

confidence: 99%

Vitamin C Nutriture in Newly Diagnosed Diabetes

Shim

Paik

Shin

et al. 2010

J Nutr Sci Vitaminol

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“…Moreover, it seems to decrease the binding affinity of the AT1 receptor by angiotensin II by disrupting the ATR1 disulfide bridges [51].…”

Section: Vitaminsmentioning

confidence: 99%

Nutraceuticals and Blood Pressure Control: Results from Clinical Trials and Meta-Analyses

Cicero

Colletti

2015

High Blood Press Cardiovasc Prev

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Beyond the well-known effects on blood pressure (BP) of the dietary approaches to stop hypertension (DASH) and the Mediterranean diets, a large number of studies has investigated the possible BP lowering effect of different dietary supplements and nutraceuticals, the most part of them being antioxidant agents with a high tolerability and safety profile. In particular relatively large body of evidence support the use of potassium, L-arginine, vitamin C, cocoa flavonoids, beetroot juice, coenzyme Q10, controlled-release melatonin, and aged garlic extract. However there is a need for data about the long-term safety of a large part of the above discussed products. Moreover further clinical research is advisable to identify between the available active nutraceuticals those with the best cost-effectiveness and risk-benefit ratio for a large use in general population with low-added cardiovascular risk related to uncomplicated hypertension.

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“…A serum level of 100 μmol/L is recommended [1,70,71] . The SBP and 24 ABM show the most significant reductions with chronic oral administration of Vitamin C [200][201][202][203][204][205] . Block et al [206] in an elegant depletion-repletion study of vitamin C demonstrated an inverse correlation of plasma ascorbate levels, SBP and DBP.…”

Section: Fibermentioning

confidence: 95%

“…Dietary intake of vitamin C and plasma ascorbate concentration in humans is inversely correlated to SBP, DBP and heart rate [196][197][198][199][200][201][202][203][204][205][206][207][208][209][210] . An evaluation of published clinical trials indicate that vitamin C dosing at 250 mg twice daily will significantly lower SBP 5-7 mmHg and diastolic BP 2-4 mmHg over 8 wk [196][197][198][199][200][201][202][203][204][205][206][207][208][209][210] . Vitamin C will induce a sodium water diuresis, improve arterial compliance, improve endothelial function, increase nitric oxide and PGI2, decrease adrenal steroid production, improve sympathovagal balance, increase RBC Na/K ATPase, increase SOD, improve aortic elasticity and compliance, improve flow mediated vasodilation, decrease pulse wave velocity and augmentation index, increase cyclic GMP, activate potassium channels, reduce cytosolic calcium and reduce serum aldehydes [208] .…”

Section: Fibermentioning

confidence: 99%

“…Vitamin C prevents ED induced by an oral glucose load. Vitamin C enhances the efficacy of amlodipine, decreases the binding affinity of the AT 1 receptor for angiotensin Ⅱ by disrupting the ATR1 disulfide bridges and enhances the anti-hypertensive effects of medications in the elderly Houston M. Hypertension, nutrition, nutritional supplements, cardiovascular disease with refractory hypertension [1,70,71,[200][201][202][203][204][205] . In elderly patients with refractory hypertension already on maximum pharmacologic therapy, 600 mg of vitamin C daily lowered the BP by 20/16 mmHg [205] .…”

Section: Fibermentioning

confidence: 99%

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The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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Ascorbic Acid Decreases the Binding Affinity of the AT1 Receptor for Angiotensin II

Cited by 32 publications

References 28 publications

Vitamin C Nutriture in Newly Diagnosed Diabetes

Vitamin C Nutriture in Newly Diagnosed Diabetes

Nutraceuticals and Blood Pressure Control: Results from Clinical Trials and Meta-Analyses

The role of nutrition and nutraceutical supplements in the treatment of hypertension

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