Ascorbic Acid in Man and Animals

Limiting light-induced lipid peroxidation and vitamin loss in infant parenteral nutrition by adding multivitamin preparations to Intralipid

“…Oxidation of ascorbate produces dehydroascorbate, which is biologically available as vitamin C but hydrolyses rapidly and irreversibly to diketogulonic acid and other degradation products including oxalate (29). Therefore, extensive ascorbate oxidation could result in precipitation of calcium oxalate and may increase the risk of kidney stone formation.…”

Ascorbic acid in fetal human brain

“…A mean plasma ascorbic acid level in late pregnancy of 0 4 to 0 5 mg/100 ml (Tables II and III) probably indicates a daily intake of 40 to 60 mg (Martin et al, 1957;Goldsmith, 1961) at which tissues may not be completely saturated (Burch, 1961;Knox and Goswami, 1961). However, during vitamin C deficiency plasma levels may fall conspicuously before depletion of leucocytes (Lowry, 1952), so that a possible tissue deficit needs to be investigated more directly by examination of leucocyte levels in a similar group of pregnant women.…”

Total Body, Plasma and Erythrocyte Potassium and Leucocyte Ascorbic Acid in ‘Ultra-Fit’ Subjects

“…The highest concentration of ascorbic acid in the mammalian body is in the adrenal gland (Knox & Goswani, 1961) and, although there is doubt as to its precise role in steroid metabolism (Kitabchi, 1967), there is an inverse relationship between the amount of ascorbic acid in the gland and the increased activity of the gland in states of stress (Booker, Da Costa, Tureman, Froix & Jones, 1955). It has been shown that after a major stressful event such as a myocardial infarction (Hume et al, 1972) or a minor stressful event such as the common cold (Hume & Weyers, 1973) there is a marked fall in the LAA within 24 h of the event and, in myocardial infarction, the LAA only gradually reaches normal levels at the end of 2 weeks, and, for the common cold, at the end of 5 days, which coincides with the healing of the disease.…”