Ascorbic Acid: Its Role in Immune System and Chronic Inflammation Diseases

Sorice, Angela; Guerriero, Eliana; Capone, Francesca; Colonna, Giovanni; Castello, Giuseppe; Costantini, Susan

doi:10.2174/1389557514666140428112602

Cited by 185 publications

(126 citation statements)

References 86 publications

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“…Vitamin C: The immune-enhancing roles of vitamin C are well established [12,13]. Vitamin C regulates the immune system because of its antioxidant properties and its role in collagen synthesis required for stabilization of epithelial barriers.…”

Section: Immune Function and Upper Respiratory Tract Infectionsmentioning

confidence: 99%

Vitamins C, D and Zinc: Synergistic Roles in Immune Function and Infections

Maggini¹,

Maldonado²,

Cardim³

et al. 2017

Vitam Miner

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The immune system is a complex and sophisticated network of specialized tissues, organs, cells, proteins, and chemicals which has evolved in order to protect the host from a range of dangerous agents such as bacteria, virus, fungi, and parasites. There is a close relationship between nutritional status and immune function. Hence, immunocompetence can be regarded as a measure of adequate nutrition. Inter-individual variations in many immune functions exist within the normal healthy population and are due to age, genetics, gender, ethnic background, socioeconomic situation, diet, stress, habitual levels of exercise, alcohol consumption, smoking habits, etc. In addition, seasonal and temperature changes as well as being in crowded spaces (e.g., while commuting in public means of transportation, or working in open space offices) pose an additional burden on the immune system. Here we review the literature on the immune supportive properties of vitamins C, D and zinc and the impact of their supplementation in reducing the incidence or ameliorating symptoms of upper respiratory tract infections, which are among the most common infections in humans. Finally, we discuss their relevance in situations known to challenge the immune system such as exposure to temperature changes, to pollutants, or being in crowded spaces which serve as mixers where pathogens can stay suspended and transfer from host to host thereby increasing the risk of spreading infectious diseases because of close contact and long exposure.

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Section: Immune Function and Upper Respiratory Tract Infectionsmentioning

confidence: 99%

Vitamins C, D and Zinc: Synergistic Roles in Immune Function and Infections

Maggini¹,

Maldonado²,

Cardim³

et al. 2017

Vitam Miner

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“…Skin disease such as atopic dermatitis, psoriasis, and acne are related by the immune response and ROS . Vitamin C has the ability to remove the ROS and has anti‐inflammation effect . Aptamin C prevents oxidation of vitamin c and maximizes its efficacy through slow release.…”

Section: Introductionmentioning

confidence: 99%

Advances in dermatology using DNA aptamer “Aptamin C” innovation: Oxidative stress prevention and effect maximization of vitamin C through antioxidation

Choi¹,

Han

Kim³

et al. 2019

J of Cosmetic Dermatology

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Background Vitamin C (also known as L‐ascorbic acid) plays a critical role in reactive oxygen species (ROS) reduction and cell regeneration by protecting cell from oxidative stress. Although vitamin C is widely used in cosmetic and therapeutic markets, there is considerable evidence that vitamin C easily undergoes oxidation by air, pH, temperature, and UV light upon storage. This deficiency of vitamin C decreases its potency as an antioxidant and reduces the shelf‐life of products containing vitamin C as its ingredient. To overcome the deficiency of vitamin C, we have developed Aptamin C, an innovative DNA aptamer maximizing the antioxidant efficacy of vitamin C by binding to the reduced form of vitamin C and delaying its oxidation. Methods Binding of Aptamin C with vitamin C was determined using ITC analysis. ITC experiment was performed 0.2 mmol/L vitamin C that was injected 25 times in 2 µL aliquots into the 1.8 mL sample cell containing the Aptamin C at a concentration of 0.02 mmol/L. The data were fitted to a one‐site binding isotherm using with origin program for ITC v.5.0. Results To investigate the effect of Aptamin C and vitamin C complex in human skins, both in vitro and clinical tests were performed. We observed that the complex of Aptamin C and vitamin C was significantly effective in wrinkle improvement, whitening effect, and hydration increase. In the clinical test, subjects treated with the complex showed dramatic improvement in skin irritation and itching. No adverse reaction was presented by Aptamin C complex in the test. Conclusion Taken together, these results showed that Aptamin C, an innovative novel compound, should potentially be served as a key cosmeceutical ingredient for a range of skin conditions.

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“…Ascorbic acid is critical for maintaining a healthy immune system and reducing chronic inflammatory diseases . The ascorbic acid content varies among fruits and vegetables .…”

Section: Resultsmentioning

confidence: 99%